牙周炎腹膜透析患者龈下菌群的特征。
Characterization of the subgingival microbiota in the peritoneal dialysis patients with periodontitis.
机构信息
Department of Periodontology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, China; Department of Stomatology, Eye and Dental Diseases Prevention and Treatment Center of Pudong New Area, Shanghai, China.
Department of Periodontology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, China.
出版信息
Arch Oral Biol. 2020 Jul;115:104742. doi: 10.1016/j.archoralbio.2020.104742. Epub 2020 May 7.
BACKGROUND AND OBJECTIVE
Periodontitis is an oral chronic inflammatory disease caused by dental plaque. It is comorbid with numerous systemic diseases and associated with several predisposing factors, such as chronic kidney disease (CKD). Peritoneal dialysis is one of the ultimate treatments for patients with severe CKD. However, peritoneal dialysis patients with periodontitis often will be accompanied with more poor oral hygiene and periodontal clinical indexes. This study aimed to compare the microbial flora of periodontitis patients with or without peritoneal dialysis.
METHODS
Sixteen peritoneal dialysis patients with periodontitis (P group) and 16 patients with periodontitis only (C group) were selected. Subgingival plaque samples of them were processed for bioinformatics analysis by 16S rDNA gene sequencing.
RESULTS
The diversity indices and species richness in the P group were insignificantly higher than that in the C group (P > 0.05). The two groups exhibited different microbial community structure. At Genus level, Prevotellaceae, Selenomonas, Aggregatibacter, Anaeroglobus, TM7_[G-5], and Centipeda were significantly enriched in the P group than those in the C group.
CONCLUSIONS
This study demonstrated that specific microbes enriched in the subgingival flora of peritoneal dialysis patients with periodontitis.
背景与目的
牙周炎是一种由牙菌斑引起的口腔慢性炎症性疾病。它与许多系统性疾病并存，并与一些易患因素有关，如慢性肾脏病（CKD）。腹膜透析是严重 CKD 患者的最终治疗方法之一。然而，患有牙周炎的腹膜透析患者往往口腔卫生状况较差，牙周临床指标也较差。本研究旨在比较有或没有腹膜透析的牙周炎患者的微生物菌群。
方法
选择 16 例腹膜透析伴牙周炎患者（P 组）和 16 例单纯牙周炎患者（C 组）。对他们的龈下菌斑样本进行 16S rDNA 基因测序的生物信息学分析。
结果
P 组的多样性指数和物种丰富度与 C 组相比无显著差异（P>0.05）。两组的微生物群落结构不同。属水平上，普雷沃氏菌科、唾液单胞菌属、聚集杆菌属、厌氧杆菌属、TM7_[G-5]和中肠涡虫属在 P 组中的丰度明显高于 C 组。
结论
本研究表明，牙周炎合并腹膜透析患者龈下菌群中存在特定的微生物富集。
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