Li Ling, Zhang Ya-Li, Liu Xing-Yu, Meng Xiang, Zhao Rong-Quan, Ou Lin-Lin, Li Bao-Zhu, Xing Tian
School of Stomatology, Anhui Medical University, Hefei, China.
Key Laboratory of Oral Diseases Research of Anhui Province, College and Hospital of Stomatology, Anhui Medical University, Hefei, China.
Front Microbiol. 2021 Jun 11;12:656372. doi: 10.3389/fmicb.2021.656372. eCollection 2021.
Periodontitis is a type of systemic immune inflammation that is caused by the complex infection of a variety of microorganisms in the subgingival plaque and the imbalance of the microbial ecological environment in the mouth. Periodontitis and chronic kidney disease (CKD) share many risk factors, such as obesity, smoking, and age. A growing body of data supports a strong correlation between periodontitis and kidney disease. Evidence supports the role of periodontal inflammation and elevated serum inflammatory mediators in renal atherosclerosis, renal deterioration, and end-stage renal disease (ESRD) development. Periodontitis is a risk factor for kidney disease. However, to our knowledge, there are few studies detailing the possible link between periodontitis and CKD. This review summarizes the possible mechanisms underlying periodontitis and CKD. More importantly, it highlights novel and potential pathogenic factors for CKD, including bacteria, pro-inflammatory mediators and oxidative stress. However, most research on the relationship between periodontitis and systemic disease has not determined causality, and these diseases are largely linked by bidirectional associations. Future research will focus on exploring these links to contribute to new treatments for CKD.
牙周炎是一种全身性免疫炎症，由龈下菌斑中多种微生物的复杂感染以及口腔微生物生态环境失衡引起。牙周炎和慢性肾脏病（CKD）有许多共同的危险因素，如肥胖、吸烟和年龄。越来越多的数据支持牙周炎与肾脏疾病之间存在密切关联。有证据表明牙周炎症和血清炎症介质升高在肾动脉粥样硬化、肾脏恶化和终末期肾病（ESRD）发展中起作用。牙周炎是肾脏疾病的一个危险因素。然而，据我们所知，很少有研究详细阐述牙周炎与CKD之间可能的联系。本综述总结了牙周炎与CKD潜在的机制。更重要的是，它强调了CKD新的和潜在的致病因素，包括细菌、促炎介质和氧化应激。然而，大多数关于牙周炎与全身性疾病关系的研究尚未确定因果关系，这些疾病在很大程度上是由双向关联联系起来的。未来的研究将集中于探索这些联系，为CKD的新治疗方法做出贡献。
