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在 COVID-19 大流行期间的节拍口服长春瑞滨和肺癌治疗:单中心经验。

Metronomic oral vinorelbine and lung cancer therapy during the COVID 19 pandemic: A single-center experience.

机构信息

Struttura Complessa di Oncologia Medica, Azienda Ospedaliera "Ospedali Riuniti Marche Nord", Pesaro, Italy.

出版信息

Lung Cancer. 2020 Jul;145:83-84. doi: 10.1016/j.lungcan.2020.05.001. Epub 2020 May 6.

DOI:10.1016/j.lungcan.2020.05.001
PMID:32416433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7201225/
Abstract

COVID 19 pandemic is a worldwide health emergency. Every single Hospital and Department was forced to radically modify clinical practice decreasing or stopping daily activities. Oncological patients had to carry on treatments in order to prevent disease progression and improve their quality of life. However, many health workers may be a potential source of infection if not tested with swabs but this diagnostic procedure was not suitable universally in Italy. Aiming to reduce hospitalization of our patients with advanced lung cancer, vinorelbine in its metronomic formulation is one of the best strategy. Here, we report the experience with oral vinorelbine in a few patients of our Oncology Department.

摘要

COVID-19 大流行是一场全球性的卫生紧急事件。每家医院和科室都被迫彻底改变临床实践,减少或停止日常活动。为了防止疾病进展和提高生活质量,肿瘤患者必须继续治疗。然而,如果不通过拭子进行检测,许多卫生工作者可能成为潜在的感染源,但这种诊断程序在意大利并不普遍适用。为了减少我们晚期肺癌患者的住院治疗,表柔比星节拍化疗是最好的策略之一。在这里,我们报告了我们肿瘤科几位患者口服表柔比星的经验。

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本文引用的文献

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ESMO Management and treatment adapted recommendations in the COVID-19 era: Lung cancer.ESMO 管理和治疗适应 COVID-19 时代的建议:肺癌。
ESMO Open. 2020 Jun;5(Suppl 3). doi: 10.1136/esmoopen-2020-000820.
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Challenges in lung cancer therapy during the COVID-19 pandemic.2019冠状病毒病大流行期间肺癌治疗面临的挑战。
Lancet Respir Med. 2020 Jun;8(6):542-544. doi: 10.1016/S2213-2600(20)30170-3. Epub 2020 Apr 9.
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Adverse event profile for immunotherapy agents compared with chemotherapy in solid organ tumors: a systematic review and meta-analysis of randomized clinical trials.免疫治疗药物与化疗药物在实体瘤中的不良反应谱比较:一项随机临床试验的系统评价和荟萃分析。
Ann Oncol. 2020 Jan;31(1):50-60. doi: 10.1016/j.annonc.2019.10.008.
4
An individual patient-data meta-analysis of metronomic oral vinorelbine in metastatic non-small cell lung cancer.一项关于转移性非小细胞肺癌中常规口服长春瑞滨的个体化患者数据荟萃分析。
PLoS One. 2019 Aug 20;14(8):e0220988. doi: 10.1371/journal.pone.0220988. eCollection 2019.
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PD-1 Inhibitor-Related Pneumonitis in Advanced Cancer Patients: Radiographic Patterns and Clinical Course.晚期癌症患者中与程序性死亡受体1(PD-1)抑制剂相关的肺炎:影像学表现及临床病程
Clin Cancer Res. 2016 Dec 15;22(24):6051-6060. doi: 10.1158/1078-0432.CCR-16-1320. Epub 2016 Aug 17.
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