Zarrintaj Payam, Ramsey Joshua D, Samadi Ali, Atoufi Zhaleh, Yazdi Mohsen Khodadadi, Ganjali Mohammad Reza, Amirabad Leila Mohammadi, Zangene Ehsan, Farokhi Mehdi, Formela Krzysztof, Saeb Mohammad Reza, Mozafari Masoud, Thomas Sabu
Chemical Engineering, Oklahoma State University, 420 Engineering North, Stillwater, OK 74078, United States.
Polymer Engineering Department, Faculty of Engineering, Urmia University, Urmia, Iran.
Acta Biomater. 2020 Jul 1;110:37-67. doi: 10.1016/j.actbio.2020.04.028. Epub 2020 May 15.
Poloxamers, also called Pluronic, belong to a unique class of synthetic tri-block copolymers containing central hydrophobic chains of poly(propylene oxide) sandwiched between two hydrophilic chains of poly(ethylene oxide). Some chemical characteristics of poloxamers such as temperature-dependent self-assembly and thermo-reversible behavior along with biocompatibility and physiochemical properties make poloxamer-based biomaterials promising candidates for biomedical application such as tissue engineering and drug delivery. The microstructure, bioactivity, and mechanical properties of poloxamers can be tailored to mimic the behavior of various types of tissues. Moreover, their amphiphilic nature and the potential to self-assemble into the micelles make them promising drug carriers with the ability to improve the drug availability to make cancer cells more vulnerable to drugs. Poloxamers are also used for the modification of hydrophobic tissue-engineered constructs. This article collects the recent advances in design and application of poloxamer-based biomaterials in tissue engineering, drug/gene delivery, theranostic devices, and bioinks for 3D printing. STATEMENT OF SIGNIFICANCE: Poloxamers, also called Pluronic, belong to a unique class of synthetic tri-block copolymers containing central hydrophobic chains of poly(propylene oxide) sandwiched between two hydrophilic chains of poly(ethylene oxide). The microstructure, bioactivity, and mechanical properties of poloxamers can be tailored to mimic the behavior of various types of tissues. Moreover, their amphiphilic nature and the potential to self-assemble into the micelles make them promising drug carriers with the ability to improve the drug availability to make cancer cells more vulnerable to drugs. However, no reports have systematically reviewed the critical role of poloxamer for biomedical applications. Research on poloxamers is growing today opening new scenarios that expand the potential of these biomaterials from "traditional" treatments to a new era of tissue engineering. To the best of our knowledge, this is the first review article in which such issue is systematically reviewed and critically discussed in the light of the existing literature.
泊洛沙姆，也称为普朗尼克，属于一类独特的合成三嵌段共聚物，其包含夹在两个聚环氧乙烷亲水链之间的聚环氧丙烷中心疏水链。泊洛沙姆的一些化学特性，如温度依赖性自组装和热可逆行为，以及生物相容性和物理化学性质，使得基于泊洛沙姆的生物材料成为组织工程和药物递送等生物医学应用的有前途的候选材料。泊洛沙姆的微观结构、生物活性和机械性能可以进行调整，以模拟各种类型组织的行为。此外，它们的两亲性以及自组装成胶束的潜力使它们成为有前途的药物载体，能够提高药物的可及性，使癌细胞更容易受到药物的作用。泊洛沙姆还用于疏水性组织工程构建体的改性。本文收集了基于泊洛沙姆的生物材料在组织工程、药物/基因递送、治疗诊断设备和用于3D打印的生物墨水方面设计和应用的最新进展。重要性声明：泊洛沙姆，也称为普朗尼克，属于一类独特的合成三嵌段共聚物，其包含夹在两个聚环氧乙烷亲水链之间的聚环氧丙烷中心疏水链。泊洛沙姆的微观结构、生物活性和机械性能可以进行调整，以模拟各种类型组织的行为。此外，它们的两亲性以及自组装成胶束的潜力使它们成为有前途的药物载体，能够提高药物的可及性，使癌细胞更容易受到药物的作用。然而，尚无报告系统地综述泊洛沙姆在生物医学应用中的关键作用。如今，对泊洛沙姆的研究不断发展，开启了新的局面，将这些生物材料的潜力从“传统”治疗扩展到组织工程的新时代。据我们所知，这是第一篇根据现有文献对该问题进行系统综述和批判性讨论的综述文章。
