Pluronics or poloxamers are a type of triblock copolymer. These non-ionic molecules consist of a hydrophobic block embedded in two hydrophilic parts. Pluronics have become favorite materials for use in the field of biomedical research due to having favorable physicochemical and biological properties such as amphiphilicity, solubility in ionic and non-ionic solutions, biocompatibility, biodegradability, self-assembly and low toxicity. The scope of these applications can vary from tissue engineering to drug delivery. One of the important uses of pluronics is to deliver drugs to various cancer cells. Herein we first provide an overview on variety of ploronic biomaterials. And then intensively evaluate their potential as drug delivery systems (DDSs) for treatment of solid tumors with special focus on breast cancers. After explaining the pros and cons of pluronics, the current status in clinical settings and future prospects are highlighted.