Ruberto U, D'Eufemia P, Giardini O
II Cattedra di Puericultura dell'Università degli Studi di Roma La Sapienza, Italia.
Pediatr Med Chir. 1988 Sep-Oct;10(5):475-9.
A group of 210 children, aged one to twelve years (86 males and 124 females) were sent to our Clinic with the diagnosis of microscopic hematuria. Twelve children in which microhematuria wasn't confirmed were immediately excluded; thirty children were excluded because they showed pathologic findings. The remaining 168 children were put under diagnostic examination (hematologic exams, urinoculture, abdomen radiographic, family screening). The cause of microhematuria was identified in 52 of them. The group was selected down to 116 who were then monitored for a period ranging from 1 to 9 years with periodical clinical and biohumoral controls and with diagnostic exams. Biopsies were performed only in 16 cases in which a nephropathy was suspected. Nine cases presented significant histological lesions. Seventy five children were subjected to observation for a period of over one year. After few years hematuria gradually disappeared in twenty six children. After nine years microhematuria had disappeared spontaneously in 39.9% of cases. It remained in core of 33.6% of case, for which no cause could be found. With reference to the full group of 168 children, the following pathologies have been found responsible of microhematuria: a) urinary way infections: 25 cases (14.8%) b) nephropathies: 16 cases (9.5%) c) familiar hematurias: 14 cases (8.3%) d) lithiasis: 9 cases (5.3%) e) alteration of the coagulation system: 3 cases (1.8%) f) renal hypercalciuria without lithiasis: 3 cases (1.8%) Based on these observation, we believe that careful waiting is the best tactic in the cases of monosymptomatic microhematuria.(ABSTRACT TRUNCATED AT 250 WORDS)
一组210名年龄在1至12岁的儿童(86名男性和124名女性)因镜下血尿的诊断被送到我们诊所。12名镜下血尿未得到证实的儿童立即被排除;30名儿童因有病理检查结果而被排除。其余168名儿童接受了诊断性检查(血液学检查、尿培养、腹部X光检查、家族筛查)。其中52名儿童的镜下血尿病因得以确定。该组被筛选至116名儿童,随后对其进行了1至9年的监测,期间进行定期临床和生物体液检查以及诊断性检查。仅对16例疑似肾病的病例进行了活检。9例出现明显的组织学病变。75名儿童接受了一年以上的观察。几年后,26名儿童的血尿逐渐消失。9年后,39.9%的病例镜下血尿自发消失。33.6%的病例镜下血尿依然存在,病因不明。关于全部168名儿童,已发现以下病理情况导致镜下血尿:a)尿路 感染:25例(14.8%);b)肾病:16例(9.5%);c)家族性血尿:14例(8.3%);d)结石:9例(5.3%);e)凝血系统改变:3例(1.8%);f)无结石的肾高钙尿症:3例(1.8%)。基于这些观察结果,我们认为对于单纯症状性镜下血尿病例,谨慎观察是最佳策略。(摘要截选至250字)