Salehi Zahra, Almasi-Hashiani Amir, Sahraian Mohammad Ali, Eskandarieh Sharareh
Immunology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Epidemiology, School of Health, Arak University of Medical Sciences, Arak, Iran.
Mult Scler Relat Disord. 2020 Aug;43:102178. doi: 10.1016/j.msard.2020.102178. Epub 2020 May 14.
Familial multiple sclerosis (FMS) studies are valuable as they reveal the effects of environment and genes on the etiology of the disease.
The present study was carried out to examine the significant variables related to the risk of FMS and its epidemiological characteristics.
This cross-sectional population-based study was conducted on 21,580 MS patients registered in the Iranian MS Society (IMSS) registry system of Tehran from 1999 to 2018. P-values < 0.05 were considered significant.
Familial MS was found among 13.04% of patients. The age-standardized prevalence of FMS increased from 9.3 to 18.3 per 100,000 people during the study period. The FMS recurrence was found to be significantly higher among women as compared with men (P-value = 0.001). Most of FMS patients were 18-29 years of age at disease onset, and the mean age of onset was 28.49 years. The occurrence rate of pediatric MS was higher in patients with FMS as compared with those without a history of MS (8.1% vs. 6.6%, respectively). The majority of FMS cases were observed among first-degree relatives, with the highest rate in male siblings (35.38%). The results indicated that the probability of MS occurrence among the offspring of mothers with MS (7.99%) was higher than its probability among the offspring of fathers with MS (2.34%).
The increasing prevalence of FMS in Tehran over time emphasizes the importance of conducting more investigations on the substantial role of genetic and environmental factors in FMS pathogenesis and inheritance.
家族性多发性硬化症（FMS）研究很有价值，因为它们揭示了环境和基因对该疾病病因的影响。
本研究旨在检查与FMS风险及其流行病学特征相关的显著变量。
这项基于人群的横断面研究针对1999年至2018年在德黑兰伊朗多发性硬化症协会（IMSS）登记系统中登记的21580例MS患者进行。P值<0.05被认为具有统计学意义。
13.04%的患者中发现有家族性MS。在研究期间，FMS的年龄标准化患病率从每10万人中的9.3例增加到18.3例。发现女性FMS复发率显著高于男性（P值=0.001）。大多数FMS患者发病时年龄在18 - 29岁，平均发病年龄为28.49岁。与无MS病史的患者相比，FMS患者中儿童MS的发生率更高（分别为8.1%和6.6%）。大多数FMS病例出现在一级亲属中，男性兄弟姐妹中的发生率最高（35.38%）。结果表明，患有MS的母亲的后代患MS的概率（7.99%）高于患有MS的父亲的后代（2.34%）。
随着时间的推移，德黑兰FMS患病率的增加强调了对基因和环境因素在FMS发病机制和遗传中的重要作用进行更多研究的重要性。
