Department of Epidemiology, School of Health, Arak University of Medical Sciences, Arak, Iran.
Multiple Sclerosis Research Center, Sina Hospital, Hassan Abad square, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
BMC Neurol. 2020 May 2;20(1):169. doi: 10.1186/s12883-020-01747-8.
The epidemiological characteristics of multiple sclerosis (MS) have been investigated in various studies, which have revealed that the prevalence of MS varies across countries. The present study was conducted to investigate the longitudinal prevalence of MS in Tehran, Iran.
The present population-based study was conducted in Tehran, the capital of Iran from 1999 to 2018 based on the annual report data provided by the Iranian MS Society (IMSS) registry system. The age-standardized and crude prevalence were estimated using population data presented by the Statistical Centre of Iran.
A total of 21,580 MS cases were registered and included in the analysis. Among the participant patients, 24.99% (5393) and 75.01% (16,187) of cases were male and female, respectively. The mean age of MS onset was 28.8 years (S.D: 8.7). The age-standardized prevalence (ASP) of MS increased from 73.7 (95%CI: 72.1-75.2) per 100,000 people in 2006 to 137.6 (95% CI: 135.7-139.5) per 100,000 people in 2018. The ASP of MS in 2018 was estimated to be 67.9 (95%CI: 66.0-69.8) and 207.3 (95%CI: 204.0-210.7) per 100,000 people among males and females, respectively. The age-standardized female-to-male ratio of MS ranged from 3.7 (in 2010) to 2.06 (in 2017).
The findings of this study suggested that the prevalence of MS in Tehran province is relatively high, and the occurrence of the disease is more common in the age groups under 40 years as compared with older-aged groups. In line with reports provided for various regions of the world, the prevalence of MS was higher among women. Similarly, the findings of this study revealed that the female-to-male ratio was 2.14 in 2018.
多项研究已经调查了多发性硬化症（MS）的流行病学特征，这些研究揭示了 MS 的患病率在各国之间存在差异。本研究旨在调查伊朗德黑兰的 MS 纵向患病率。
本基于伊朗多发性硬化症协会（IMSS）注册系统提供的年度报告数据，在伊朗首都德黑兰进行了这项基于人群的研究。使用伊朗统计中心提供的人口数据，估算了年龄标准化和原始患病率。
共登记了 21580 例 MS 病例，并纳入了分析。在参与者患者中，男性占 24.99%（5393 例），女性占 75.01%（16187 例）。MS 发病的平均年龄为 28.8 岁（标准差：8.7）。MS 的年龄标准化患病率（ASP）从 2006 年每 10 万人 73.7（95%CI：72.1-75.2）增加到 2018 年的每 10 万人 137.6（95%CI：135.7-139.5）。2018 年，男性和女性的 MS ASP 分别估计为每 10 万人 67.9（95%CI：66.0-69.8）和 207.3（95%CI：204.0-210.7）。MS 的年龄标准化女性与男性比值范围为 3.7（2010 年）至 2.06（2017 年）。
本研究的结果表明，德黑兰省的 MS 患病率相对较高，与年龄较大的人群相比，疾病发生更常见于 40 岁以下的年龄组。与世界各地报告的数据一致，MS 在女性中的患病率更高。同样，本研究的结果表明，2018 年女性与男性的比例为 2.14。
