Department of Paediatrics, University of Cambridge, Cambridge, UK; Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt.
Department of Paediatrics, Faculty of Medicine, Cairo University, Egypt.
J Clin Virol. 2020 Jul;128:104395. doi: 10.1016/j.jcv.2020.104395. Epub 2020 May 8.
Coronavirus disease 2019 (COVID-19) is a pandemic first originated in Wuhan the capital of Hubei province, China in December 2019 and then spread globally. It is caused by SARS-CoV-2. Until 1 April 2020, the number of cases worldwide was recorded to be 823,626 with 40,598 deaths. Most of the reported cases were adults with few cases described in children and neonates.
We performed a systematic review and meta-analysis to analyse the disease characterisation in paediatric age group including the possibility of vertical transmission to the neonates.
Articles published up to 2 April 2020 in PubMed and google Scholar were considered for this study.
The most frequently reported symptoms were cough 49% (95% CI: 42 - 55%) and fever 47% (95% CI: 41- 53%). Lymphopenia and increased Procalcitonin were recorded in (21%, 95% CI: 12 - 30%) and (28%, 95% CI: 18 - 37%) respectively. No sex difference for COVID-19 was found in paediatric age group (p = 0.7). Case fatality rate was 0%. Four out of 58 neonates (6.8%) born to COVID-19 confirmed mothers tested positive for the disease.
The disease trajectory in Paediatric patients has good prognosis compared to adults. Intensive care unit and death are rare. Vertical transmission and virus shedding in breast milk are yet to be established.
2019 年冠状病毒病（COVID-19）是一种大流行疾病，于 2019 年 12 月首次在中国湖北省省会武汉出现，随后在全球范围内传播。它是由 SARS-CoV-2 引起的。截至 2020 年 4 月 1 日，全球报告的病例数为 823,626 例，死亡 40,598 例。大多数报告的病例是成年人，只有少数儿童和新生儿病例。
我们进行了一项系统评价和荟萃分析，以分析儿科年龄组的疾病特征，包括向新生儿垂直传播的可能性。
本研究考虑了截至 2020 年 4 月 2 日在 PubMed 和谷歌学术上发表的文章。
最常报告的症状是咳嗽 49%（95%可信区间：42-55%）和发热 47%（95%可信区间：41-53%）。淋巴细胞减少和降钙素原升高分别为 21%（95%可信区间：12-30%）和 28%（95%可信区间：18-37%）。儿科年龄组中未发现 COVID-19 的性别差异（p=0.7）。病死率为 0%。在 58 名出生于 COVID-19 确诊母亲的新生儿中，有 4 名（6.8%）检测出该病毒阳性。
与成人相比，儿科患者的疾病轨迹预后良好。重症监护病房和死亡很少见。垂直传播和母乳中病毒脱落尚未确定。
