儿童感染 SARS-CoV-2 的特征及粪便中持续存在病毒的潜在证据。
Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding.
机构信息
Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Department of Center Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
出版信息
Nat Med. 2020 Apr;26(4):502-505. doi: 10.1038/s41591-020-0817-4. Epub 2020 Mar 13.
We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. Chest X-rays lacked definite signs of pneumonia, a defining feature of the infection in adult cases. Notably, eight children persistently tested positive on rectal swabs even after nasopharyngeal testing was negative, raising the possibility of fecal-oral transmission.
我们报告了十例经实时逆转录聚合酶链反应（RT-PCR）检测 SARS-CoV-2 RNA 确诊的儿童 SARS-CoV-2 感染病例的流行病学和临床调查。这些病例的症状无特异性，无患儿需要呼吸支持或重症监护。胸部 X 线片缺乏肺炎的明确征象，这是成人感染的特征性表现。值得注意的是，8 例患儿直肠拭子检测持续阳性，即使鼻咽拭子检测为阴性，提示存在粪-口传播的可能。
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