On the mechanism of antiaggregatory effect of myricetin.
作者信息
Robak J, Korbut R, Shridi F, Swies J, Rzadkowska-Bodalska H
机构信息
Department of Pharmacology, N. Copernicus Academy of Medicine, Kraków, Poland.
出版信息
Pol J Pharmacol Pharm. 1988 May-Jun;40(3):337-40.
PMID:3241773
Abstract
Myricetin at a dose of 3.6 micrograms/kg iv was found to inhibit the cat blood platelet aggregation in vivo. It disaggregated platelet thrombi in vitro at a concentration of 60 nM. This flavonoid bound to platelet membranes and prevented prostacyclin synthase against oxygen free radicals owing to its antioxidant properties. Myricetin inhibited soybean lipoxygenase when linoleic acid was used as a substrate.
摘要
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