Department of Psychiatry, University of Cambridge, UK.
Centre for Dementia Prevention, University of Edinburgh, UK.
J Alzheimers Dis. 2020;75(4):1211-1218. doi: 10.3233/JAD-200238.
Alzheimer's disease (AD) begins decades before the onset of dementia. There is a need to investigate biomarkers of early AD for use in clinical trials and to facilitate early intervention.
We aimed to determine whether changes in hippocampal subfield volumes in healthy middle-aged adults were associated with risk of future dementia.
We included 150 participants from the PREVENT-Dementia cohort, which recruited subjects aged 40-59 with or without a family history of dementia (FHD; included here were 81 with FHD and 69 without). Hippocampal subfield volumes were segmented from high resolution T2-weighted 3T MRI images taken at baseline and 2-year follow-up.
FHD and greater 20 year-risk of dementia due to cardiovascular risk factors were both associated with lower CA1 volume. FHD was also associated with a relative increase in combined CA3, CA4, and dentate gyrus volume between baseline and follow-up.
CA1 atrophy may commence as early as middle-age in those with a high risk of future dementia, while increases in CA3, CA4, and dentate gyrus volume may be a response to early AD in the form of inflammation or neurogenesis.
阿尔茨海默病（AD）在痴呆症发作前数十年就开始了。有必要研究 AD 的早期生物标志物，以便用于临床试验并促进早期干预。
我们旨在确定健康中年成年人的海马亚区体积变化是否与未来痴呆症的风险相关。
我们纳入了 PREVENT-Dementia 队列的 150 名参与者，该队列招募了 40-59 岁的有或没有痴呆家族史（FHD；这里包括 81 名有 FHD 和 69 名没有 FHD）的受试者。在基线和 2 年随访时，使用高分辨率 T2 加权 3T MRI 图像对海马亚区体积进行分割。
FHD 和由于心血管危险因素导致的 20 年痴呆风险较高均与 CA1 体积减少有关。FHD 还与基线和随访之间 CA3、CA4 和齿状回的体积总和相对增加有关。
在未来有较高痴呆风险的人群中，CA1 萎缩可能早在中年就开始了，而 CA3、CA4 和齿状回体积的增加可能是炎症或神经发生形式的早期 AD 的反应。
