低海马下托体积作为老年痴呆症风险易感性的指标
Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age.
作者信息
Kagerer Sonja M, Schroeder Clemens, van Bergen Jiri M G, Schreiner Simon J, Meyer Rafael, Steininger Stefanie C, Vionnet Laetitia, Gietl Anton F, Treyer Valerie, Buck Alfred, Pruessmann Klaas P, Hock Christoph, Unschuld Paul G
机构信息
Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
Psychogeriatric Medicine, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
出版信息
Front Aging Neurosci. 2022 Mar 3;14:811146. doi: 10.3389/fnagi.2022.811146. eCollection 2022.
INTRODUCTION
Hippocampal atrophy is an established Alzheimer's Disease (AD) biomarker. Volume loss in specific subregions as measurable with ultra-high field magnetic resonance imaging (MRI) may reflect earliest pathological alterations.
METHODS
Data from positron emission tomography (PET) for estimation of cortical amyloid β (Aβ) and high-resolution 7 Tesla T1 MRI for assessment of hippocampal subfield volumes were analyzed in 61 non-demented elderly individuals who were divided into risk-categories as defined by high levels of cortical Aβ and low performance in standardized episodic memory tasks.
RESULTS
High cortical Aβ and low episodic memory interactively predicted subicular volume [(3,57) = 5.90, = 0.018]. The combination of high cortical Aβ and low episodic memory was associated with significantly lower subicular volumes, when compared to participants with high episodic memory ( = 0.004).
DISCUSSION
Our results suggest that low subicular volume is linked to established indicators of AD risk, such as increased cortical Aβ and low episodic memory. Our data support subicular volume as a marker of dementia-risk susceptibility in old-aged non-demented persons.
引言
海马萎缩是一种公认的阿尔茨海默病（AD）生物标志物。通过超高场磁共振成像（MRI）测量特定亚区域的体积损失可能反映最早的病理改变。
方法
对61名非痴呆老年人进行了分析，这些老年人接受了用于评估皮质淀粉样β蛋白（Aβ）的正电子发射断层扫描（PET）数据以及用于评估海马亚区域体积的高分辨率7特斯拉T1 MRI数据，他们根据皮质Aβ水平高和标准化情景记忆任务表现低被分为不同风险类别。
结果
高皮质Aβ和低情景记忆交互预测了下托体积[（3,57）= 5.90，= 0.018]。与情景记忆高的参与者相比，高皮质Aβ和低情景记忆的组合与显著更低的下托体积相关（= 0.004）。
讨论
我们的结果表明，低下托体积与AD风险的既定指标相关，如皮质Aβ增加和情景记忆低。我们的数据支持下托体积作为老年非痴呆人群痴呆风险易感性的标志物。
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