Department of Cell Biology and Genetics, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, 350122, Fujian, China.
Key Laboratory of Stem Cell Engineering and Regenerative Medicine, Fujian Province University, Fuzhou, 350122, Fujian, China.
Chromosoma. 2020 Jun;129(2):99-110. doi: 10.1007/s00412-020-00736-7. Epub 2020 May 17.
Microtubules are essential for intracellular transport, cell motility, spindle assembly, and chromosome segregation during cell division. Microtubule dynamics regulate the proper spindle organization and thus contribute to chromosome congression and segregation. Accumulating studies suggest that kinesin-8 motors are emerging regulators of microtubule dynamics and organizations. In this review, we provide an overview of the studies focused on kinesin-8 motors in cell division. We discuss the structures and molecular kinetics of kinesin-8 motors. We highlight the essential roles and mechanisms of kinesin-8 in the regulation of microtubule dynamics and spindle organization. We also shed light on the functions of kinesin-8 motors in chromosome movement and the spindle assembly checkpoint during the cell cycle.
微管对于细胞内运输、细胞运动、纺锤体组装和细胞分裂期间的染色体分离至关重要。微管动力学调节适当的纺锤体组织，从而有助于染色体向心和分离。越来越多的研究表明，驱动蛋白-8 马达是微管动力学和组织的新兴调节因子。在这篇综述中，我们提供了一个关于细胞分裂中驱动蛋白-8 马达的研究概述。我们讨论了驱动蛋白-8 马达的结构和分子动力学。我们强调了驱动蛋白-8 在调节微管动力学和纺锤体组织中的重要作用和机制。我们还揭示了驱动蛋白-8 马达在染色体运动和细胞周期中的纺锤体组装检查点中的功能。
