成人海马神经发生在重度抑郁症和阿尔茨海默病中的作用。
Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer's Disease.
机构信息
Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London and South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Monks Orchard Road, Beckenham, Kent, UK.
出版信息
Trends Mol Med. 2020 Sep;26(9):803-818. doi: 10.1016/j.molmed.2020.03.010. Epub 2020 May 14.
Depression and dementia are major public health problems. Major depressive disorder (MDD) and Alzheimer's disease (AD) reciprocally elevate the risk for one another. No effective drug is available to treat AD and about one-third of depressive patients show treatment resistance. The biological connection between MDD and AD is still unclear. Uncovering this link might open novel ways of treatment and prevention to improve patient healthcare. Here, we discuss recent studies specifically on the role of human adult hippocampal neurogenesis (AHN) in MDD and AD. We compare diverse approaches to analyse the effect of MDD and AD on human AHN and analyse different studies implicating the role of human AHN as a potential converging mechanism in MDD and AD.
抑郁和痴呆是主要的公共卫生问题。重度抑郁症（MDD）和阿尔茨海默病（AD）相互增加彼此的发病风险。目前尚无有效的药物可用于治疗 AD，约三分之一的抑郁患者表现出治疗抵抗。MDD 和 AD 之间的生物学联系尚不清楚。揭示这一联系可能为改善患者的医疗保健提供新的治疗和预防方法。在这里，我们讨论了最近关于人类成年海马神经发生（AHN）在 MDD 和 AD 中作用的具体研究。我们比较了不同的方法来分析 MDD 和 AD 对人类 AHN 的影响，并分析了不同的研究，这些研究表明人类 AHN 作为 MDD 和 AD 中的一个潜在的趋同机制的作用。
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