阿尔茨海默病中的成年海马神经发生：通往临床相关性的路线图。
Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance.
机构信息
Laboratory of Neurogenesis and Neurodegeneration, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.
Department of Anatomy and Cell Biology, College of Medicine, The University of Illinois at Chicago, 808 S Wood St., Chicago, IL 60612, USA.
出版信息
Cell Stem Cell. 2023 Feb 2;30(2):120-136. doi: 10.1016/j.stem.2023.01.002.
Abstract
Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients. Understanding AHN regulation in AD could provide a framework for innovative pharmacological interventions. We here combine molecular, behavioral, and clinical data and critically discuss the multicellular complexity of the AHN niche in relation to AD pathophysiology. We further present a roadmap toward a better understanding of the role of AHN in AD by probing the promises and caveats of the latest technological advancements in the field and addressing the conceptual and methodological challenges ahead.
摘要
成人海马神经发生（AHN）在阿尔茨海默病（AD）的早期阶段急剧下降，其机制尚不清楚，并与 AD 患者的认知状态相关。了解 AD 中 AHN 的调节机制可为创新的药物干预提供框架。在这里，我们结合了分子、行为和临床数据，并批判性地讨论了 AHN 生态位与 AD 病理生理学相关的多细胞复杂性。我们进一步提出了一条理解 AHN 在 AD 中作用的途径，通过探索该领域最新技术进步的前景和挑战，并解决未来的概念和方法学挑战。
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