Department of Neurobiology & Behavior, SUNY at Stony Brook, Stony Brook, NY 11794, USA.
Medical Scientist Training Program (MSTP), Renaissance School of Medicine at SUNY, Stony Brook, Stony Brook, NY 11794, USA.
Zool Res. 2022 May 18;43(3):481-496. doi: 10.24272/j.issn.2095-8137.2021.479.
Adult neurogenesis is the creation of new neurons which integrate into the existing neural circuit of the adult brain. Recent evidence suggests that adult hippocampal neurogenesis (AHN) persists throughout life in mammals, including humans. These newborn neurons have been implicated to have a crucial role in brain functions such as learning and memory. Importantly, studies have also found that hippocampal neurogenesis is impaired in neurodegenerative and neuropsychiatric diseases. Alzheimer's disease (AD) is one of the most common forms of dementia affecting millions of people. Cognitive dysfunction is a common symptom of AD patients and progressive memory loss has been attributed to the degeneration of the hippocampus. Therefore, there has been growing interest in identifying how hippocampal neurogenesis is affected in AD. However, the link between cognitive decline and changes in hippocampal neurogenesis in AD is poorly understood. In this review, we summarized the recent literature on AHN and its impairments in AD.
成人神经发生是指新神经元的产生，这些神经元会整合到成年大脑的现有神经网络中。最近的证据表明，包括人类在内的哺乳动物的成年海马神经发生（AHN）在整个生命过程中都持续存在。这些新生神经元被认为在学习和记忆等大脑功能中起着至关重要的作用。重要的是，研究还发现海马神经发生在神经退行性和神经精神疾病中受到损害。阿尔茨海默病（AD）是最常见的痴呆症之一，影响着数百万人。认知功能障碍是 AD 患者的常见症状，而进行性记忆丧失归因于海马体的退化。因此，人们越来越关注识别 AD 中海马神经发生是如何受到影响的。然而，AD 中认知能力下降与海马神经发生变化之间的联系还知之甚少。在这篇综述中，我们总结了最近关于 AHN 及其在 AD 中的损伤的文献。
