Lemmer Björn, Middeke Martin
Institue of Pharmacology & Toxicology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg , Frankfurt, Germany.
Hypertension Centre Munic, An Excellence Centre of the European Society of Hypertension (ESH) , München, Germany.
Chronobiol Int. 2020 May;37(5):728-730. doi: 10.1080/07420528.2020.1761374. Epub 2020 May 18.
The recently published chronotherapeutic Spanish papers MAPEC and HYGIA proposing that antihypertensive drug treatment should be given at bedtime suffers from obvious deficiencies in study design and are not a valid basis for drug treatment of hypertension.
最近发表的关于时间治疗学的西班牙论文MAPEC和HYGIA提出应在睡前给予抗高血压药物治疗,但这些研究在设计上存在明显缺陷,并非高血压药物治疗的有效依据。