Salmanroghani Hassan, Akbarian Samira, Roghani Roham Salman
Department of Internal Medicine, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Tehran University Internal Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Maedica (Bucur). 2020 Mar;15(1):71-75. doi: 10.26574/maedica.2020.15.1.71.
Quality of disease is improved in patients with pancreatic cancer via endoscopic placement of a biliary stent. Since the role of non-cover metal stent inside the biliary duct is not definitely clear, the aim of this study was to evaluate the recurrence of obstructive symptoms and quality of life after insertion of non-cover metal stent inside the biliary duct in patients with pancreatic cancer. This retrospective descriptive-analytical study was conducted on 81 patients with pancreatic cancer who were referred to Mortaz and Shahaid Sadoughi Hospital. Factors such as pruritus, jaundice, appetite, stomachache and general situation were measured. Quality of life assessment was performed using the Functional Assessment of Cancer Therapy-Hepatobiliary questionnaire (version 4). Then, the quality of life score was classified in terms of median score (more and less than 18). Patients had a mean age of 72±12.15 years. The most complete recovery among them was related to jaundice (54.3%) and pruritus (47.4%). Subjects had a mean quality of life score of 21.60±6.24. Moreover, the mean quality of life score of 37.2% and 62.8% of patients was less and more than the median value, respectively. In addition, there was no significant difference between frequency of recurrence in terms of variables including sex, age, death, chemotherapy, surgery, and quality of life (p>0.05). The mean recurrence time was 6.9±5.03 months. According to our findings, the quality of life score of most patients using metal stent is higher than 18. Therefore, it seems that the use of metal stent can improve the quality of life score in these patients. Stenting also improves jaundice and pruritus in these subjects. In addition, because there is no significant relation between the frequency of recurrence with age, mortality, chemotherapy, and quality of life, it can be concluded that none of the above factors affects the frequency of recurrence among patients with pancreatic cancer.
通过内镜放置胆管支架可改善胰腺癌患者的疾病质量。由于胆管内无覆膜金属支架的作用尚不完全明确，本研究旨在评估胰腺癌患者胆管内插入无覆膜金属支架后梗阻症状的复发情况及生活质量。本回顾性描述性分析研究对81例转诊至莫尔塔兹和沙希德·萨杜基医院的胰腺癌患者进行。测量了瘙痒、黄疸、食欲、胃痛和一般状况等因素。使用癌症治疗功能评估-肝胆问卷（第4版）进行生活质量评估。然后，根据中位数评分（大于和小于18）对生活质量评分进行分类。患者的平均年龄为72±12.15岁。其中恢复最完全的是黄疸（54.3%）和瘙痒（47.4%）。受试者的平均生活质量评分为21.60±6.24。此外，分别有37.2%和62.8%的患者的平均生活质量评分低于和高于中位数。此外，在性别、年龄、死亡、化疗、手术和生活质量等变量方面，复发频率之间没有显著差异（p>0.05）。平均复发时间为6.9±5.03个月。根据我们的研究结果，大多数使用金属支架的患者的生活质量评分高于18。因此，似乎使用金属支架可以提高这些患者的生活质量评分。支架置入术还可改善这些受试者的黄疸和瘙痒。此外，由于复发频率与年龄、死亡率、化疗和生活质量之间没有显著关系，可以得出结论，上述因素均不影响胰腺癌患者的复发频率。
