Baggus Elisabeth Megan Rose, Hadjivassiliou Marios, Cross Simon, Penny Hugo, Urwin Heidi, Watson Sarah, Woodward Jeremy Mark, Sanders David S
Academic Unit of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK.
Coeliac UK, High Wycombe, Buckinghamshire, UK.
Frontline Gastroenterol. 2019 Aug 8;11(3):235-242. doi: 10.1136/flgastro-2019-101191. eCollection 2020.
Adult coeliac disease (CD) affects approximately 1% of the population. Most patients diagnosed will respond to a gluten-free diet; however, up to 30% may have persisting symptoms. Such patients may have ongoing issues associated with adherence, non-responsive CD or refractory CD. This article provides a clinical overview of how to manage this group of patients with persisting symptoms, including an investigational algorithm and details of how to contact the National Health Service England Rare Diseases Collaborative Network for Non-Responsive and Refractory Coeliac Disease. We hope this will be a valuable source of contemporary information for all UK gastroenterologists and internationally.
成人乳糜泻（CD）影响约1%的人口。大多数被诊断出的患者对无麸质饮食有反应；然而，高达30%的患者可能会有持续症状。这类患者可能存在与依从性、无反应性CD或难治性CD相关的持续问题。本文提供了如何管理这组有持续症状患者的临床概述，包括一个调查算法以及如何联系英国国家医疗服务体系英格兰罕见病协作网络以获取关于无反应性和难治性乳糜泻的详细信息。我们希望这将成为所有英国胃肠病学家以及国际上当代信息的宝贵来源。
