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基于红薯的代餐种子汁(MRSJ)对CCl诱导的HepG2细胞毒性的肝脏保护作用。

Hepatoprotective effect of meal replacement seeds juice based on sweet potato (MRSJ) against CCl-induced cytotoxicity in HepG2 cells.

作者信息

Park Hye-Jung, Lee Song Min, Kim Hee Sook, Kim Ji-Youn, Lee Sang-Hyeon, Jang Jeong Su, Lee Mun Hyon

机构信息

Food Research Center, Angel Co., Ltd., Busan, 46988 Korea.

2Major in Pharmaceutical Engineering, Division of Bioindustry, College of Medical and Life Sciences, Silla University, Busan, 46958 Korea.

出版信息

Food Sci Biotechnol. 2019 Nov 28;29(5):693-704. doi: 10.1007/s10068-019-00709-2. eCollection 2020 May.

DOI:10.1007/s10068-019-00709-2
PMID:32419968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7221099/
Abstract

A sweet potato-based Meal Replacement Seeds Juice (MRSJ) was developed by mixing sweet potatoes and carrots with four types of seeds. Consuming the MRSJ rather than the whole vegetables or whole seeds improved digestive function, proving that it is suitable for the elderly. Its rich composition of minerals, vitamins, and unsaturated fatty acids implicates it as an excellent nutrient source. Notably, the ethyl acetate fraction of MRSJ contains abundant phenolics. The antioxidant activity assays showed that these phenolics have high radical scavenging activity, reducing power, and antioxidant capacity similar to l-ascorbic acid. The ethyl acetate fraction exerted protective effects against CCl- or HO-induced hepatotoxicity via DNA protection, lipid accumulation inhibition, and cell protection, wherein ALT and AST activities in the cell culture solution decreased significantly. These findings suggest that MRSJ consumption may protect against liver diseases. Moreover, MRSJ as an excellent nutrient source may be developed as an age-neutral food.

摘要

通过将红薯、胡萝卜与四种种子混合,研发出了一种以红薯为基础的代餐种子汁(MRSJ)。食用MRSJ而非完整的蔬菜或种子可改善消化功能,证明其适合老年人。其丰富的矿物质、维生素和不饱和脂肪酸成分表明它是一种优质的营养来源。值得注意的是,MRSJ的乙酸乙酯部分含有丰富的酚类物质。抗氧化活性测定表明,这些酚类物质具有较高的自由基清除活性、还原能力和抗氧化能力,与L-抗坏血酸相似。乙酸乙酯部分通过DNA保护、脂质积累抑制和细胞保护对CCl或HO诱导的肝毒性发挥保护作用,其中细胞培养液中的ALT和AST活性显著降低。这些发现表明,食用MRSJ可能预防肝脏疾病。此外,MRSJ作为一种优质的营养来源,可被开发为一种不分年龄段的食品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f5/7221099/54518a821031/10068_2019_709_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f5/7221099/2afbd221e117/10068_2019_709_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f5/7221099/25e13de56b43/10068_2019_709_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f5/7221099/0eb9c93b358f/10068_2019_709_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f5/7221099/54518a821031/10068_2019_709_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f5/7221099/2afbd221e117/10068_2019_709_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f5/7221099/25e13de56b43/10068_2019_709_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f5/7221099/0eb9c93b358f/10068_2019_709_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f5/7221099/54518a821031/10068_2019_709_Fig4_HTML.jpg

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