• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

From precision medicine to imprecision medicine through limited diagnostic ability to detect low allelic frequency mutations.

作者信息

Serrano María José, Exposito-Hernández José, Guerrero Rosa, Lopez-Hidalgo Javier, Aguilar Mariano, Lorente Jose A, de Álava Enrique, Garrido-Navas M Carmen

机构信息

GENYO, Centre for Genomics and Oncological Research (Pfizer/University of Granada/Andalusian Regional Government), PTS Granada, Granada, Spain.

Integral Oncology Division, Virgen de las Nieves University Hospital, Granada, Spain.

出版信息

Transl Lung Cancer Res. 2020 Apr;9(2):180-183. doi: 10.21037/tlcr.2020.03.07.

DOI:10.21037/tlcr.2020.03.07
PMID:32420057
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7225138/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1dd/7225138/74d8f4be3e22/tlcr-09-02-180-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1dd/7225138/74d8f4be3e22/tlcr-09-02-180-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1dd/7225138/74d8f4be3e22/tlcr-09-02-180-f1.jpg

相似文献

1
From precision medicine to imprecision medicine through limited diagnostic ability to detect low allelic frequency mutations.从精准医学到不精准医学:通过有限的诊断能力来检测低等位基因频率突变。
Transl Lung Cancer Res. 2020 Apr;9(2):180-183. doi: 10.21037/tlcr.2020.03.07.
2
BIOMEDICAL RESEARCH. Countering imprecision in precision medicine.生物医学研究。应对精准医学中的不精确性。
Science. 2016 Jul 29;353(6298):448-9. doi: 10.1126/science.aaf5101.
3
The impact of companion diagnostic device measurement performance on clinical validation of personalized medicine.伴随诊断设备测量性能对个性化医疗临床验证的影响。
Stat Med. 2015 Jun 30;34(14):2222-34. doi: 10.1002/sim.6476. Epub 2015 Mar 16.
4
Biomarker imprecision in precision medicine.精准医学中的生物标志物不精确性。
Expert Rev Mol Diagn. 2018 Aug;18(8):685-687. doi: 10.1080/14737159.2018.1493379. Epub 2018 Jul 6.
5
Cancer risk and clinicopathological characteristics of thyroid nodules harboring thyroid-stimulating hormone receptor gene mutations.携带促甲状腺激素受体基因突变的甲状腺结节的癌症风险及临床病理特征
Diagn Cytopathol. 2018 May;46(5):369-377. doi: 10.1002/dc.23915. Epub 2018 Mar 8.
6
Analytical imprecision of lactate dehydrogenase in primary serum tubes.一次性血清管中乳酸脱氢酶的分析不精密度。
Ann Clin Biochem. 2016 May;53(Pt 3):405-8. doi: 10.1177/0004563215595644. Epub 2015 Jun 25.
7
Precision or imprecision medicine?精准医学还是非精准医学?
Nat Rev Clin Oncol. 2016 Nov 18;13(12):713. doi: 10.1038/nrclinonc.2016.190.
8
Time perception and patience: individual differences in interval timing precision predict choice impulsivity in European starlings, Sturnus vulgaris.时间感知和耐心:欧洲椋鸟(Sturnus vulgaris)个体在时间间隔精度上的差异预测了其选择冲动性。
Anim Cogn. 2021 Jul;24(4):731-745. doi: 10.1007/s10071-020-01456-2. Epub 2021 Jan 12.
9
A strategy to discover genes that carry multi-allelic or mono-allelic risk for common diseases: a cohort allelic sums test (CAST).一种发现携带常见疾病多等位基因或单等位基因风险的基因的策略:队列等位基因总和检验(CAST)。
Mutat Res. 2007 Feb 3;615(1-2):28-56. doi: 10.1016/j.mrfmmm.2006.09.003. Epub 2006 Nov 13.
10
Precision medicine review: rare driver mutations and their biophysical classification.精准医学综述:罕见驱动突变及其生物物理分类
Biophys Rev. 2019 Feb;11(1):5-19. doi: 10.1007/s12551-018-0496-2. Epub 2019 Jan 4.

引用本文的文献

1
The Polemic Diagnostic Role of Mutations in Liquid Biopsies from Breast, Colon and Lung Cancers.乳腺癌、结肠癌和肺癌液体活检中突变的争议性诊断作用
Cancers (Basel). 2020 Nov 12;12(11):3343. doi: 10.3390/cancers12113343.

本文引用的文献

1
T790M detection rate in lung adenocarcinomas at baseline using droplet digital PCR and validation by ultra-deep next generation sequencing.使用液滴数字PCR检测肺腺癌基线时的T790M突变率,并通过超深度二代测序进行验证。
Transl Lung Cancer Res. 2019 Oct;8(5):584-592. doi: 10.21037/tlcr.2019.09.18.
2
Intrinsic resistance to EGFR-Tyrosine Kinase Inhibitors in -Mutant Non-Small Cell Lung Cancer: Differences and Similarities with Acquired Resistance.EGFR突变型非小细胞肺癌对表皮生长因子受体酪氨酸激酶抑制剂的内在耐药性:与获得性耐药的异同
Cancers (Basel). 2019 Jul 1;11(7):923. doi: 10.3390/cancers11070923.
3
Evaluation of EGFR mutations in NSCLC with highly sensitive droplet digital PCR assays.
采用高敏感液滴数字 PCR 法检测非小细胞肺癌中的 EGFR 突变。
Mol Med Rep. 2019 Jul;20(1):593-603. doi: 10.3892/mmr.2019.10259. Epub 2019 May 21.
4
Concurrent Driver Gene Mutations as Negative Predictive Factors in Epidermal Growth Factor Receptor-Positive Non-Small Cell Lung Cancer.表皮生长因子受体阳性非小细胞肺癌中共同驱动基因突变作为负预测因素。
EBioMedicine. 2019 Apr;42:304-310. doi: 10.1016/j.ebiom.2019.03.023. Epub 2019 Mar 14.
5
Personalized medicine in non-small cell lung cancer: a review from a pharmacogenomics perspective.非小细胞肺癌中的个性化医疗:从药物基因组学角度的综述
Acta Pharm Sin B. 2018 Jul;8(4):530-538. doi: 10.1016/j.apsb.2018.04.005. Epub 2018 Apr 30.
6
Molecular profiling of lung cancer specimens and liquid biopsies using MALDI-TOF mass spectrometry.使用基质辅助激光解吸电离飞行时间质谱法对肺癌标本和液体活检进行分子谱分析。
Diagn Pathol. 2018 Jan 12;13(1):4. doi: 10.1186/s13000-017-0683-7.
7
Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology.美国病理学家学会、国际肺癌研究协会和分子病理学会更新的肺癌患者靶向酪氨酸激酶抑制剂治疗选择的分子检测指南。
Arch Pathol Lab Med. 2018 Mar;142(3):321-346. doi: 10.5858/arpa.2017-0388-CP. Epub 2018 Jan 22.
8
Variants with a low allele frequency detected in genomic DNA affect the accuracy of mutation detection in cell-free DNA by next-generation sequencing.在基因组 DNA 中检测到的低频等位基因突变会影响下一代测序技术在游离 DNA 中的突变检测准确性。
Cancer. 2018 Mar 1;124(5):1061-1069. doi: 10.1002/cncr.31152. Epub 2017 Nov 27.
9
Prevalence and detection of low-allele-fraction variants in clinical cancer samples.临床癌症样本中低频等位基因变异的流行和检测。
Nat Commun. 2017 Nov 9;8(1):1377. doi: 10.1038/s41467-017-01470-y.
10
Panel based MALDI-TOF tumour profiling is a sensitive method for detecting mutations in clinical non small cell lung cancer tumour.基于芯片的基质辅助激光解吸电离飞行时间质谱肿瘤分析是检测临床非小细胞肺癌肿瘤突变的一种灵敏方法。
PLoS One. 2014 Jun 23;9(6):e100566. doi: 10.1371/journal.pone.0100566. eCollection 2014.