Department of Chemistry, Faculty of Science, Arak University, Arak 38156-8-8349, Iran.
Department of Chemistry, Faculty of Science, Arak University, Arak 38156-8-8349, Iran; Department of Nanosciences & Nanotechnology, Arak University, Arak, Iran.
Int J Biol Macromol. 2020 Sep 15;159:598-606. doi: 10.1016/j.ijbiomac.2020.05.086. Epub 2020 May 16.
Here, we develop homogeneous hydrogel networks containing zinc tetraamino-phthalocyanine (ZnTAPc) as photosensitizer cross-linked with glutaraldehyde. The cross-linking process occurs via imine bond formation by reaction of NH groups of ZnTAPc and chitosan with aldehyde groups of the glutaraldehyde. Insertion of ZnTAPc interestingly increases its solubility in water medium. 2.0% and 4% w/w of the ZnTAPc were used with respect to chitosan polymer to generate hydrogel photosensitizer. FT-IR and UV-Vis spectroscopy, scanning electron microscopy, and rheological measurements were applied to evaluate the properties of the prepared hydrogels. Finally, difloxacin HCl was selected as a fluoroquinolone drug for the assessment of the drug release features of the made hydrogels. The difloxacin release was affected by the amount of ZnTAPc and pH medium. The activity of the hydrogels in photosensitizing process was considered by computing the rate of 1,3-diphenylisobenzofuran adsorption reduction as a singlet oxygen chemical quencher.
在这里，我们开发了含有锌四氨基酞菁（ZnTAPc）作为光敏剂的均相水凝胶网络，该光敏剂通过 ZnTAPc 和壳聚糖中的 NH 基团与戊二醛中的醛基反应形成亚胺键进行交联。有趣的是，ZnTAPc 的插入增加了其在水介质中的溶解度。相对于壳聚糖聚合物，使用了 2.0%和 4%重量比的 ZnTAPc 来生成水凝胶光敏剂。应用傅里叶变换红外光谱（FT-IR）和紫外可见光谱（UV-Vis）、扫描电子显微镜（SEM）和流变学测量来评估所制备水凝胶的性质。最后，选择盐酸二氟沙星作为氟喹诺酮类药物来评估所制水凝胶的药物释放特性。ZnTAPc 的用量和 pH 值介质影响了二氟沙星的释放。通过计算 1,3-二苯基异苯并呋喃作为单线态氧化学猝灭剂的吸附还原速率来考虑水凝胶在光敏化过程中的活性。
