Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Curr Opin Genet Dev. 2020 Aug;63:53-60. doi: 10.1016/j.gde.2020.04.001. Epub 2020 May 15.
Developing embryos can adapt dynamically to noise and variation to generate organs of incredible precision, a process termed 'canalization'; however, the underlying robustness mechanisms are poorly understood. Technological developments, both in quantitative imaging and high precision perturbation, are now enabling targeted investigation into developmental robustness in vivo. Here, we will first distil the common design features of studies that have exploited the canalization behaviour of specific systems to interrogate developmental adaptation, to provide a general experimental framework for future investigations in other contexts. We will then highlight, using a selection of recent case studies, how this approach is revealing that tissues and embryos can fix themselves in unexpected ways.
发育中的胚胎能够动态适应噪声和变化，从而生成具有惊人精度的器官，这一过程被称为“ canalization ”；然而，其背后的稳健性机制还不太清楚。定量成像和高精度扰动方面的技术发展，现在使我们能够在体内针对发育稳健性进行有针对性的研究。在这里，我们将首先提炼出利用特定系统的 canalization 行为来研究发育适应的研究的共同设计特点，为在其他情况下进行未来研究提供一个通用的实验框架。然后，我们将通过选择一些最近的案例研究来强调，这种方法如何揭示出组织和胚胎能够以出人意料的方式自我修复。
