Pavelek Zbyšek, Angelucci Francesco, Souček Ondřej, Krejsek Jan, Sobíšek Lukáš, Klímová Blanka, Šarláková Jana, Halúsková Simona, Kuča Kamil, Vališ Martin
Department of Neurology, Faculty of Medicine and University Hospital Hradec Králové, Charles University in Prague, Sokolská 581, 500 05 Hradec Kralove, Czech Republic.
Memory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu 84, 150 06 Prague, Czech Republic.
J Clin Med. 2020 May 14;9(5):1468. doi: 10.3390/jcm9051468.
BACKGROUND: Multiple sclerosis (MS) is a neurodegenerative disease that affects the central nervous system. The cause of MS is still unknown, and the role of innate immunity is still poorly understood. OBJECTIVE: The goal of this study was to understand whether, compared to healthy controls, the elements of innate immunity are altered in the blood of MS patients in the remitting phase. METHODS: A total of 77 naïve MS patients and 50 healthy controls were included in this cohort study. Peripheral blood samples were collected and analyzed. All the calculations were performed with the statistical system R (r-project.org). RESULTS: The results showed that MS patients had significantly lower relative representations of granulocytes than healthy controls, while the relative representations of monocytes remained unchanged. CD64- and PD-L1-positive granulocytes exhibited a nonsignificant decreasing trend, while granulocytes with other membrane markers remained noticeably unchanged. CONCLUSION: The results of this study suggest that studies of the causes of MS and its treatment should also be focused on the elements of the innate immune response.
背景：多发性硬化症（MS）是一种影响中枢神经系统的神经退行性疾病。MS的病因仍不清楚，先天免疫的作用也仍未得到充分理解。 目的：本研究的目的是了解与健康对照相比，缓解期MS患者血液中先天免疫成分是否发生改变。 方法：本队列研究共纳入77例初发MS患者和50例健康对照。采集外周血样本并进行分析。所有计算均使用统计系统R（r-project.org）进行。 结果：结果显示，MS患者粒细胞的相对比例显著低于健康对照，而单核细胞的相对比例保持不变。CD64和PD-L1阳性粒细胞呈现出不显著的下降趋势，而具有其他膜标记物的粒细胞则明显保持不变。 结论：本研究结果表明，对MS病因及其治疗的研究也应关注先天免疫反应的成分。
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