Wang Zhantong, Gao Haiyan, Zhang Yang, Liu Gang, Niu Gang, Chen Xiaoyuan
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD 20892, USA.
Front Chem Sci Eng. 2017 Dec;11(4):633-646. doi: 10.1007/s11705-017-1620-8. Epub 2017 Feb 15.
Ferritin, a major iron storage protein with a hollow interior cavity, has been reported recently to play many important roles in biomedical and bioengineering applications. Owing to the unique architecture and surface properties, ferritin nanoparticles offer favorable characteristics and can be either genetically or chemically modified to impart functionalities to their surfaces, and therapeutics or probes can be encapsulated in their interiors by controlled and reversible assembly/disassembly. There has been an outburst of interest regarding the employment of functional ferritin nanoparticles in nanomedicine. This review will highlight the recent advances in ferritin nanoparticles for drug delivery, bioassay, and molecular imaging with a particular focus on their biomedical applications.
铁蛋白是一种内部有中空腔室的主要铁储存蛋白，最近有报道称其在生物医学和生物工程应用中发挥着许多重要作用。由于其独特的结构和表面性质，铁蛋白纳米颗粒具有良好的特性，并且可以通过基因或化学修饰赋予其表面功能，治疗剂或探针可以通过可控的可逆组装/拆卸封装在其内部。人们对功能性铁蛋白纳米颗粒在纳米医学中的应用兴趣激增。本综述将重点介绍铁蛋白纳米颗粒在药物递送、生物测定和分子成像方面的最新进展，特别关注其生物医学应用。
