Johnson Sean, Imai Shin-Ichiro
Department of Developmental Biology, Washington University School of Medicine, St. Louis, USA.
F1000Res. 2018 Feb 1;7:132. doi: 10.12688/f1000research.12120.1. eCollection 2018.
Nicotinamide adenine dinucleotide (NAD ) biosynthesis and its regulation have recently been attracting markedly increasing interest. Aging is marked by a systemic decrease in NAD across multiple tissues. The dysfunction of NAD biosynthesis plays a critical role in the pathophysiologies of multiple diseases, including age-associated metabolic disorders, neurodegenerative diseases, and mental disorders. As downstream effectors, NAD -dependent enzymes, such as sirtuins, are involved in the progression of such disorders. These recent studies implicate NAD biosynthesis as a potential target for preventing and treating age-associated diseases. Indeed, new studies have demonstrated the therapeutic potential of supplementing NAD intermediates, such as nicotinamide mononucleotide and nicotinamide riboside, providing a proof of concept for the development of an effective anti-aging intervention.
烟酰胺腺嘌呤二核苷酸（NAD）的生物合成及其调控近来受到了显著增加的关注。衰老的特征是多个组织中NAD的系统性减少。NAD生物合成功能障碍在多种疾病的病理生理过程中起关键作用，包括与年龄相关的代谢紊乱、神经退行性疾病和精神障碍。作为下游效应器，NAD依赖性酶，如去乙酰化酶，参与了这些疾病的进展。这些最新研究表明，NAD生物合成是预防和治疗与年龄相关疾病的潜在靶点。事实上，新的研究已经证明了补充NAD中间体，如烟酰胺单核苷酸和烟酰胺核糖的治疗潜力，为开发有效的抗衰老干预措施提供了概念验证。
