School of Pharmacy, North China University of Science and Technology, Tangshan, Hebei 063210, P. R. China.
School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, P. R. China.
J Org Chem. 2020 Jun 19;85(12):8279-8286. doi: 10.1021/acs.joc.0c00963. Epub 2020 Jun 2.
A mild, catalyst- and metal-free photochemical protocol for the oxygenation of 3-cyano-1,4-dihydropyridines to 5-cyano-2-pyridones was developed. Utilizing molecular oxygen from the air as the oxidant and a cheap blue LED lamp as the light source, a variety of 3-cyano-1,4-dihydropyridines were converted into the corresponding 5-cyano-2-pyridones in moderate to excellent yields. Exploration of the substrate scope revealed that 3-cyano and 4-aryl groups play an important role in the formation of 2-pyridone.
开发了一种温和、无催化剂和金属的光化学方法，用于将 3-氰基-1,4-二氢吡啶氧化为 5-氰基-2-吡啶酮。利用空气中的分子氧作为氧化剂和廉价的蓝色 LED 灯作为光源，多种 3-氰基-1,4-二氢吡啶在中等至优异的收率下转化为相应的 5-氰基-2-吡啶酮。对底物范围的探索表明，3-氰基和 4-芳基在 2-吡啶酮的形成中起着重要作用。
