Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Biofunctional Materials and Devices Research Group, National Metal and Materials Technology Center (MTEC), Pathum Thani, Thailand.
Proc Inst Mech Eng H. 2020 Aug;234(8):854-863. doi: 10.1177/0954411920926071. Epub 2020 May 19.
Ideally, alloplastic dural substitute should have functional properties resembling human dura mater and retain a watertight closure to prevent cerebrospinal leakage. Therefore, functional properties for successful dural closure application of newly developed bilayer oxidized regenerated cellulose knitted fabric/poly ε-caprolactone knitted fabric-reinforced composites were studied and compared with human cadaveric dura mater and three commercial dural substitutes including two collagen matrices and one synthetic poly-L-lactide patch. It was found that oxidized regenerated cellulose knitted fabric/poly ε-caprolactone knitted fabric-reinforced composites uniquely contained a bilayer structure consisting of micropores distributed within the relatively dense microstructure. Density, tensile properties and stitch tear strength of oxidized regenerated cellulose knitted fabric/poly ε-caprolactone knitted fabric-reinforced composites were found to be closed to human cadaveric dura mater than those of dense-type and porous-type dural substitutes. Water tightness performance in both sutured and non-sutured forms of oxidized regenerated cellulose knitted fabric/poly ε-caprolactone knitted fabric-reinforced composites was slightly inferior to human cadaveric dura mater, but still better than those of commercial dural substitutes. This study revealed that oxidized regenerated cellulose knitted fabric/poly ε-caprolactone knitted fabric-reinforced composite showed better functional properties than typical dural substitutes and was found to be a good candidate for being employed as a dural substitute. The role and relationship of both microstructure and the type of materials on the functional properties and water tightness of the dural substitutes were also elucidated.
理想情况下，同种异体硬脑膜替代物应具有类似于人类硬脑膜的功能特性，并保持水密性以防止脑脊液漏。因此，研究了新开发的双层氧化再生纤维素针织/聚 ε-己内酯针织增强复合材料用于成功硬脑膜闭合的功能特性，并将其与人体硬脑膜和三种商业硬脑膜替代物（包括两种胶原基质和一种合成聚 L-丙交酯补片）进行了比较。结果发现，氧化再生纤维素针织/聚 ε-己内酯针织增强复合材料独特地包含了一种双层结构，其中微孔分布在相对致密的微观结构内。氧化再生纤维素针织/聚 ε-己内酯针织增强复合材料的密度、拉伸性能和缝线撕裂强度比致密型和多孔型硬脑膜替代物更接近人体硬脑膜。缝合和非缝合形式的氧化再生纤维素针织/聚 ε-己内酯针织增强复合材料的水密性性能略逊于人体硬脑膜，但仍优于商业硬脑膜替代物。本研究表明，氧化再生纤维素针织/聚 ε-己内酯针织增强复合材料的功能特性优于典型的硬脑膜替代物，是作为硬脑膜替代物的良好候选材料。本研究还阐明了微观结构和材料类型对硬脑膜替代物的功能特性和水密性的作用和关系。
