Department of Geriatric Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Department of Geriatric Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Am J Med Sci. 2020 Jul;360(1):64-71. doi: 10.1016/j.amjms.2020.04.004. Epub 2020 Apr 10.
The association between uric acid and N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) in patients with unstable angina pectoris (UAP) is unclear.
We recruited 260 patients with UAP admitted to the first affiliated Hospital of Guangxi Medical University from February 2018 to August 2018. According to the level of uric acid, patients were divided into 4 groups (Q1 = 48.00-305.00 μmol/L; Q2 = 310.00-405.00 μmol/L; Q3 = 408.00-513.00 μmol/L; Q4 = 514.00-4330.00 μmol/L). The differences of NT-proBNP between groups and the relationship with cardiac function were compared.
The average age of the 260 patients enrolled was 75.04 years. The NT-proBNP of the 4 groups showed an increasing trend, and there were significant differences between the 4 groups (<0.001). On the other hand, with the increase of cardiac function (New York Heart Association), the levels of NT-proBNP and uric acid also showed an upward trend (all P < 0.05). Pearson correlation analysis showed that there was a positive correlation between uric acid log10 transform and NT-proBNP log10 transform (r = 0.272, P < 0.001). After adjusting the potential confounding factors, elevated uric acid was still significantly related to the increase of NT-proBNP (Q2 versus [vs.] Q1: OR = 469.64, 95%CI -1396.77 to 2336.05; Q3 vs. Q1: OR = 1166.53, 95%CI -726.12 to 3059.18; Q4 vs. Q1: OR = 3204.78, 95%CI 1240.86-5168.70). In subgroup analysis, the relationship between uric acid and NT-proBNP was significant in males, but no difference was observed in females.
In male patients with UAP, elevated uric acid is related to the increase of NT-proBNP, but this phenomenon is not obvious in female patients.
尿酸与不稳定型心绞痛（UAP）患者的 N 端脑利钠肽前体（NT-proBNP）之间的关系尚不清楚。
我们招募了 2018 年 2 月至 2018 年 8 月期间广西医科大学第一附属医院收治的 260 例 UAP 患者。根据尿酸水平，将患者分为 4 组（Q1 = 48.00-305.00 μmol/L；Q2 = 310.00-405.00 μmol/L；Q3 = 408.00-513.00 μmol/L；Q4 = 514.00-4330.00 μmol/L）。比较各组 NT-proBNP 的差异及与心功能的关系。
260 例患者的平均年龄为 75.04 岁。4 组的 NT-proBNP 呈递增趋势，组间比较差异有统计学意义（<0.001）。另一方面，随着心功能（纽约心脏协会）的增加，NT-proBNP 和尿酸水平也呈上升趋势（均 P < 0.05）。Pearson 相关分析显示，尿酸 log10 转换与 NT-proBNP log10 转换之间呈正相关（r = 0.272，P < 0.001）。调整潜在混杂因素后，尿酸升高仍与 NT-proBNP 增加显著相关（Q2 与 Q1 相比：OR = 469.64，95%CI-1396.77 至 2336.05；Q3 与 Q1 相比：OR = 1166.53，95%CI-726.12 至 3059.18；Q4 与 Q1 相比：OR = 3204.78，95%CI 1240.86 至 5168.70）。亚组分析显示，尿酸与 NT-proBNP 之间的关系在男性中显著，但在女性中无差异。
在男性 UAP 患者中，尿酸升高与 NT-proBNP 增加有关，但在女性患者中这一现象并不明显。
