调解在生殖健康研究中的重要性。
The importance of mediation in reproductive health studies.
机构信息
Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Department of Mathematics & Statistics, Amherst College, Amherst, MA, USA.
出版信息
Hum Reprod. 2020 Jun 1;35(6):1262-1266. doi: 10.1093/humrep/deaa064.
Abstract
A mediator is a factor that occurs after the exposure of interest, precedes the outcome of interest (i.e. between the exposure and the outcome) and is associated with both the exposure and the outcome of interest (i.e. is on the pathway between exposure and outcome). Mediation analyses can be valuable in many reproductive health contexts, as mediation analysis can help researchers to better identify, quantify and understand the underlying pathways of the association they are studying. The purpose of this commentary is to introduce the concept of mediation and provide examples that solidify understanding of mediation for valid discovery and interpretation in the field of reproductive medicine.
摘要
中介变量是在关注的暴露因素之后、关注的结果之前出现的因素（即在暴露和结果之间），并且与关注的暴露因素和结果都相关（即处于暴露和结果之间的路径上）。在许多生殖健康背景下，中介分析都非常有价值，因为中介分析可以帮助研究人员更好地识别、量化和理解他们正在研究的关联的潜在途径。本评论的目的是介绍中介的概念，并提供一些例子，以巩固在生殖医学领域进行有效发现和解释的中介理解。
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