Peña-Egido M J, Mariño-Hernandez E L, Santos-Buelga C, Rivas-Gonzalo J C
Department of Food Science, Toxicology and Chemical Analysis, Faculty of Pharmacy, University of Salamanca, Spain.
Arch Toxicol. 1988;62(5):351-4. doi: 10.1007/BF00293622.
The urinary excretion kinetics of p-nitrophenol were studied in rabbits following oral administration of parathion at a dose of 3 mg/kg. Elimination of p-nitrophenol began rapidly, and of the total amount excreted during the study period, 46% was excreted in the first 3 h; 85% was excreted at 6 h after administration of the pesticide. The mean maximum excretion rate of p-nitrophenol was 111.15 +/- 61.02 micrograms/h reached in a time of 0.77 +/- 0.26 h. The formation and disappearance rate constants of the metabolite were 2.85 +/- 2.80 h-1 and 0.80 +/- 0.28 h-1, respectively. A linear relationship was observed between the plasma concentrations of parathion and the urinary excretion rate of p-nitrophenol.
以3mg/kg的剂量给家兔口服对硫磷后，研究了对硝基苯酚的尿排泄动力学。对硝基苯酚的消除迅速开始，在研究期间排泄的总量中，46%在最初3小时内排泄；在施用农药后6小时排泄了85%。对硝基苯酚的平均最大排泄率为111.15±61.02微克/小时，在0.77±0.26小时达到。代谢物的生成和消失速率常数分别为2.85±2.80 h-1和0.80±0.28 h-1。观察到对硫磷的血浆浓度与对硝基苯酚的尿排泄率之间存在线性关系。
