Ostby Stuart A, Olushoga Michael, Leath Charles A, Burleson Samuel L
University of Alabama at Birmingham, Department of Obstetrics and Gynecology, Birmingham, Alabama.
University of Alabama at Birmingham, Department of Emergency Medicine, Birmingham, Alabama.
Clin Pract Cases Emerg Med. 2020 Mar 27;4(2):227-229. doi: 10.5811/cpcem.2020.1.45374. eCollection 2020 May.
We describe the presentation to the emergency department of a patient with recurrent ovarian cancer treated with bevacizumab with the complication of bowel perforation.
We review the frequency and outcomes of bevacizumab-related bowel perforation. We also report the patient's imaging findings, including the radiologic presentation of free intraperitoneal air and portal venous gas, both indicative of bowel perforation and the need for emergent surgical evaluation. Our case also illustrates the potentially catastrophic side effects of bevacizumab and other targeted oncologic therapies of which emergecny physicians may not be aware.
我们描述了一名复发性卵巢癌患者在接受贝伐单抗治疗后出现肠穿孔并发症并前往急诊科就诊的情况。
我们回顾了贝伐单抗相关肠穿孔的发生率和结局。我们还报告了患者的影像学检查结果，包括腹腔内游离气体和门静脉气体的影像学表现，这两者均提示肠穿孔且需要紧急进行外科评估。我们的病例还说明了贝伐单抗和其他靶向肿瘤治疗可能产生的灾难性副作用，而急诊科医生可能并不知晓这些副作用。
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