Jones L A, Baxter R J
Department of Vision Sciences, Aston University, Birmingham.
Br J Audiol. 1988 Nov;22(4):279-85. doi: 10.3109/03005368809076465.
The middle latency response (MLR) using wide band-pass filters shows marked changes in amplitude, latency and configuration in sleep. The components with latencies greater than 20 ms show the greatest variability. There is a significant increase in Pa latency in stages 2 and stages 3/4, and in some cases a disappearance of the Nb component with the development of a broad positivity of latency intermediate to Pa and Pb which dominates the response. The responses in REM are of similar latency and configuration as in wakefulness but of reduced amplitude. The 40 Hz response is markedly reduced in amplitude in all sleep stages reflecting a decrease in the contribution of the middle latency components to this composite response. This appears to arise through a loss of 40 Hz periodicity in slow wave sleep and an increase in the slow 10 Hz component. In REM sleep, there is an overall reduction in amplitude. Much of the reported variability of the MLR in the literature arises from the widely differing band-pass filters used and the inadequate control for level of arousal. Both these factors have been shown to produce significant changes in the response.
使用宽带通滤波器的中潜伏期反应（MLR）在睡眠中显示出幅度、潜伏期和波形的显著变化。潜伏期大于20毫秒的成分显示出最大的变异性。在睡眠2期和3/4期，Pa潜伏期显著增加，在某些情况下，Nb成分消失，出现了潜伏期介于Pa和Pb之间的广泛阳性波，该阳性波主导了反应。快速眼动期的反应潜伏期和波形与清醒时相似，但幅度减小。在所有睡眠阶段，40赫兹反应的幅度显著降低，这反映出中潜伏期成分对该复合反应的贡献减少。这似乎是由于慢波睡眠中40赫兹周期性的丧失以及慢的10赫兹成分的增加所致。在快速眼动睡眠中，幅度总体降低。文献中报道的MLR的许多变异性源于所使用的带通滤波器差异很大以及对觉醒水平的控制不足。这两个因素都已被证明会使反应产生显著变化。
