Erwin R, Buchwald J S
Electroencephalogr Clin Neurophysiol. 1986 Sep;65(5):383-92. doi: 10.1016/0168-5597(86)90017-1.
Middle latency responses (MLRs) in the 10-100 msec latency range, evoked by click stimuli, were studied in 14 adult volunteer subjects during sleep-wakefulness to determine whether such changes in state were reflected by any MLR component. Evoked potentials were collected in 500 trial averages during continuous presentation of 1/sec clicks during initial awake recordings and thereafter during a 2 h afternoon nap or all-night sleep session. Continuously recorded EEG, EOG and EMG were scored for wakefulness, stages 2-4 of slow wave sleep (SWS), and rapid eye movement (REM) sleep during each evoked potential epoch. The major components included in this study and their latency ranges, as determined by peak latency measurements from the awake records, were: ABR V, 5-8 msec, Pa, 30-40 msec, Nb, 45-55 msec, and P1, 55-80 msec. In agreement with previous reports, ABR V and Pa showed no amplitude changes from wakefulness to either SWS or REM. Not previously reported, however, was the dramatic decrease and disappearance of P1 during SWS and its reappearance during REM to an amplitude similar to that during wakefulness. This unique linkage between a particular evoked potential component and sleep-wakefulness indicates that its generator system must be functionally related to states of arousal. Relevant data from the cat model suggest that the generator substrate for P1 may be within the ascending reticular activating system.
在14名成年志愿者受试者的睡眠-觉醒期间，研究了由点击刺激诱发的潜伏期在10-100毫秒范围内的中潜伏期反应（MLR），以确定这种状态变化是否由任何MLR成分反映出来。在初始清醒记录期间以每秒1次的频率连续呈现点击刺激时，以及此后在下午2小时的午睡或整夜睡眠期间，以500次试验平均值收集诱发电位。在每个诱发电位时段，对连续记录的脑电图（EEG）、眼电图（EOG）和肌电图（EMG）进行觉醒、慢波睡眠（SWS）的2-4期和快速眼动（REM）睡眠评分。本研究中包括的主要成分及其潜伏期范围（由清醒记录中的峰值潜伏期测量确定）为：听觉脑干反应V波，5-8毫秒；Pa波，30-40毫秒；Nb波，45-55毫秒；P1波，55-80毫秒。与先前的报告一致，从觉醒到SWS或REM，听觉脑干反应V波和Pa波的振幅没有变化。然而，以前没有报道过的是，P1波在SWS期间急剧下降并消失，在REM期间重新出现，其振幅与觉醒期间相似。这种特定诱发电位成分与睡眠-觉醒之间的独特联系表明，其发生器系统一定在功能上与觉醒状态相关。来自猫模型的相关数据表明，P1波的发生器基质可能在上升网状激活系统内。
