Xie Mingran, Zhu Yongfu, Xu Shibin, Xu Guangwen, Xiong Ran, Sun Xiaohui, Liu Changqing
Department of Thoracic Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.
Department of Oncology, Anhui University of Tradational Chinese Medicine, Hefei 230000, China.
Nanoscale. 2020 Jun 4;12(21):11497-11509. doi: 10.1039/d0nr00123f.
Due to their high biocompatibility, high spatial resolution, chromatographic capability, and adjustable size and morphology, magnetic nanoparticles have become the most promising nanomaterials for clinical application in noninvasive imaging and drug delivery for the treatment of malignant tumors. Herein, a novel magnetic nanoparticle coated with calcium carbonate was prepared and loaded with near-infrared drugs to be used as a multifunctional theranostic nanoplatform for the diagnosis and treatment of malignant tumors. Then, these drug-loaded nanoparticles were used for combined photodynamic/photothermal therapy by intravenous administration that was simultaneously guided by fluorescence/MR imaging. Due to the targeted induction of the external magnetic field and tumor response degradation of the calcium carbonate layer, the nanoprobe demonstrated excellent tumor targeting and greatly improved drug aggregation at the tumor site. Finally, single wavelength-mediated photothermal/photodynamic therapy was applied to liver cancer model mice, ultimately achieving an exciting antitumor therapeutic effect. This study may promote further exploration of nanoplatforms based on magnetic nanoparticles for clinical application in the treatment of malignant tumors.
由于具有高生物相容性、高空间分辨率、色谱能力以及可调节的尺寸和形态，磁性纳米粒子已成为用于恶性肿瘤治疗的非侵入性成像和药物递送临床应用中最有前途的纳米材料。在此，制备了一种包覆碳酸钙并负载近红外药物的新型磁性纳米粒子，用作恶性肿瘤诊断和治疗的多功能诊疗纳米平台。然后，将这些载药纳米粒子通过静脉注射用于光动力/光热联合治疗，并同时由荧光/磁共振成像引导。由于外部磁场的靶向诱导和碳酸钙层的肿瘤响应降解，纳米探针表现出优异的肿瘤靶向性，并大大提高了药物在肿瘤部位的聚集。最后，将单波长介导的光热/光动力疗法应用于肝癌模型小鼠，最终实现了令人兴奋的抗肿瘤治疗效果。本研究可能会促进基于磁性纳米粒子的纳米平台在恶性肿瘤治疗临床应用方面的进一步探索。
