Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
CAS Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
J Nanobiotechnology. 2023 Aug 2;21(1):250. doi: 10.1186/s12951-023-01975-3.
Nano-engineering with unique "custom function" capability has shown great potential in solving technical difficulties of nanomaterials in tumor treatment. Through tuning the size and surface properties controllablly, nanoparticles can be endoewd with tailored structure, and then the characteristic functions to improve the therapeutic effect of nanomedicines. Based on nano-engineering, many have been carried out to advance nano-engineering nanomedicine. In this review, the main research related to cancer therapy attached to the development of nanoengineering nanomedicines has been presented as follows. Firstly, therapeutic agents that target to tumor area can exert the therapeutic effect effectively. Secondly, drug resistance of tumor cells can be overcome to enhance the efficacy. Thirdly, remodeling the immunosuppressive microenvironment makes the therapeutic agents work with the autoimmune system to eliminate the primary tumor and then prevent tumor recurrence and metastasis. Finally, the development prospects of nano-engineering nanomedicine are also outlined.
纳米工程具有独特的“定制功能”能力，在解决肿瘤治疗中纳米材料的技术难题方面显示出巨大的潜力。通过可控地调整尺寸和表面特性，纳米颗粒可以被包封具有定制结构，然后利用这些特征功能来提高纳米药物的治疗效果。基于纳米工程，已经开展了许多工作来推进纳米工程纳米药物的发展。在这篇综述中，主要介绍了与癌症治疗相关的研究，这些研究与纳米工程纳米药物的发展有关。首先，靶向肿瘤区域的治疗剂可以有效地发挥治疗作用。其次，可以克服肿瘤细胞的耐药性，提高疗效。第三，重塑免疫抑制微环境使治疗剂与免疫系统协同作用，以消除原发性肿瘤，然后防止肿瘤复发和转移。最后，还概述了纳米工程纳米药物的发展前景。
