Pierri I, Rogna S, Tavano A, Setti M, Scudeletti M, Ratto G, Motta G, Indiveri F
Istituto Scientifico di Medicina Interna-Patologia Medica RR, Università degli Studi di Genova, Italy.
Cancer Detect Prev. 1988;13(2):95-101.
Some serological (serum immunoglobulins, circulating immune complexes, quantitative assessment of hemolytic complement activity) and cellular (total number of circulating lymphocytes as well their phenotypic and functional characterization) parameters have been analyzed in 42 patients with lung cancer of three hystologic types and in 19 healthy controls to define whether different histologic neoplasms have an impact on the host immune system. As a group, cancer patients showed 1) the presence of circulating immune complexes, in a significant percentage, within all the three groups studied; and 2) a significant reduction of lymphocytes forming E rosette. With regard to cellular immune parameters we noted that 1) T lymphocytes isolated from the peripheral blood lymphocytes (PBL) of patients with lung cancer showed a decreased capacity to express HLA-class II antigens upon phytohemogglutinin (PHA) activation in vitro; 2) PBL from lung cancer, in particular the adenocarcinoma group, failed to proliferate upon stimulation by policlonal mitogens; and 3) the autologous mixed lymphocyte reaction (MLR) of non-T/T-type was impaired in all three groups, whereas the autologous MLR of T/T-type was impaired only in the patients with squamous cell carcinoma and in those with adenocarcinoma, probably as a result of a reduced stimulatory capacity.
对42例三种组织学类型的肺癌患者和19名健康对照者的一些血清学参数（血清免疫球蛋白、循环免疫复合物、溶血补体活性的定量评估）和细胞参数（循环淋巴细胞总数及其表型和功能特征）进行了分析，以确定不同组织学类型的肿瘤是否对宿主免疫系统有影响。总体而言，癌症患者表现出：1）在所研究的所有三组中，循环免疫复合物均有显著比例存在；2）形成E玫瑰花结的淋巴细胞显著减少。关于细胞免疫参数，我们注意到：1）从肺癌患者外周血淋巴细胞（PBL）中分离出的T淋巴细胞在体外经植物血凝素（PHA）激活后表达HLA - II类抗原的能力下降；2）肺癌患者的PBL，尤其是腺癌组，在多克隆有丝分裂原刺激下未能增殖；3）所有三组中，非T/T型的自体混合淋巴细胞反应（MLR）均受损，而T/T型的自体MLR仅在鳞状细胞癌患者和腺癌患者中受损，这可能是由于刺激能力降低所致。
