van der Veen F H, Visser R, Willems G M, Kop-Klaassen B, Hermens W T
Department of Biophysics, University of Linburg, Maastricht, The Netherlands.
Cardiovasc Res. 1988 Sep;22(9):611-9. doi: 10.1093/cvr/22.9.611.
Myocardial activities of several enzymes were measured in infarcted and non-infarcted areas of heart sections obtained from eight patients who died after acute myocardial infarction. Similar data were obtained from four patients with cardiovascular disorders who died from causes other than myocardial infarction and from six patients without previously known heart disease. It was found that both non-infarcted and infarcted tissue samples contained considerably altered enzyme activities. This finding explains the low correlations between enzymatic and histological estimates of infarct size previously reported. However, when the residual myocardial activities of different enzymes were compared with each other, a close correlation was found between creatine kinase, alpha-hydroxybutyrate dehydrogenase, and aspartate aminotransferase. It appears that the pathological changes in the myocardial activities of these enzymes may be explained by the phenomenon of diluted myocardium. This indicates that myocardial injury, as estimated from plasma enzyme activities, may still be expressed meaningfully in gram equivalents of healthy myocardium.
对8例急性心肌梗死后死亡患者心脏切片的梗死区和非梗死区的几种酶的心肌活性进行了测定。从4例死于非心肌梗死原因的心血管疾病患者和6例既往无心脏病史的患者中获得了类似的数据。结果发现，非梗死和梗死组织样本中的酶活性均有显著改变。这一发现解释了先前报道的酶学和组织学梗死面积估计之间的低相关性。然而，当比较不同酶的残余心肌活性时，发现肌酸激酶、α-羟丁酸脱氢酶和天冬氨酸转氨酶之间存在密切相关性。这些酶的心肌活性的病理变化似乎可以用心肌稀释现象来解释。这表明，从血浆酶活性估计的心肌损伤，仍可能以健康心肌的克当量有意义地表达出来。
