Bogers A J, van der Laarse A, van der Mey K H, Rasser- van der Mey A A, Hollaar L
Res Exp Med (Berl). 1983;182(2):105-9. doi: 10.1007/BF01851116.
An abdominodiaphragmal way of producing right-ventricular myocardial infarction is introduced, allowing of ligation of the right-coronary artery and vein without further manipulation of the heart. Of the rats operated upon, 22% died perioperatively. Of the surviving part, 89% had myocardial infarction macroscopically. This method was used to study enzyme decreases in infarcted myocardium. Our biochemical results correlate very well with histological and histobiochemical findings reported by other investigators. Therefore, we conclude that right-coronary artery ligation in rats by transabdominal, transdiaphragmal access to the heart can be a useful way to study biochemical aspects of infarcted myocardium.
介绍了一种经腹膈途径制造右心室心肌梗死的方法，该方法可在不进一步操作心脏的情况下结扎右冠状动脉和静脉。在接受手术的大鼠中，22%在围手术期死亡。在存活的大鼠中，89%在宏观上出现心肌梗死。该方法用于研究梗死心肌中的酶减少情况。我们的生化结果与其他研究者报道的组织学和组织生物化学结果非常吻合。因此，我们得出结论，经腹膈途径进入心脏对大鼠进行右冠状动脉结扎可成为研究梗死心肌生化方面的一种有用方法。
