Key Lab of Science and Technology of Eco-textile, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Innovation Center for Textile Science and Technology, Donghua University, No. 2999 North Renmin Road, Shanghai 201620, China.
Department of Urology and Andrology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China; Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
Int J Biol Macromol. 2020 Oct 1;160:18-25. doi: 10.1016/j.ijbiomac.2020.05.099. Epub 2020 May 16.
Uncontrolled hemorrhage is a large cause of death in the global scope, thus leading to an urgent demand to develop efficient hemostatic materials. In this study, a series of modified cotton fabrics (MCFs) with different carboxymethyl group contents were prepared from cotton fabric (CF) by a carboxymethylation process to choose the appropriate one with the best hemostatic performance. The carboxymethyl group contents of MCFs rose up as the dosages of ClCHCOOH increased. The crystallinity of CF decreased after carboxymethylation, and MCFs can dissolve slightly with the phenomenon that there were vague boundaries between fibers after being treated with water. Furthermore, the MCF with the carboxymethyl group content at 0.77 mmol/g (MCF-0.77) could absorb the blood quickly, achieve dense distribution of blood cells and have high viscosity of leaching liquor. In addition, the MCF-0.77 with good biocompatibility accelerated the hemostasis time to 46.6 ± 8.4 s compared with the CF (88.8 ± 31.5 s) in a rat model of liver injury. In summary, the prepared MCF-0.77 is a potential hemostatic wound dressing for clinical use since every second counts for pre-hospital care.
失控性出血是全球范围内导致死亡的主要原因之一，因此迫切需要开发有效的止血材料。在本研究中，通过羧甲基化过程从棉织物（CF）制备了一系列具有不同羧甲基基团含量的改性棉织物（MCF），以选择具有最佳止血性能的合适材料。随着 ClCHCOOH 用量的增加，MCF 的羧甲基基团含量增加。CF 经羧甲基化后结晶度降低，MCF 经水作用后略微溶解，纤维之间的界限变得模糊。此外，羧甲基基团含量为 0.77mmol/g 的 MCF（MCF-0.77）能够快速吸收血液，实现血细胞的密集分布，并具有较高的浸提液粘度。此外，具有良好生物相容性的 MCF-0.77 可将止血时间从 CF（88.8±31.5s）的 88.8±31.5s 加速至大鼠肝损伤模型中的 46.6±8.4s。总之，由于每一秒都对院外急救至关重要，因此制备的 MCF-0.77 是一种有潜力的临床用止血创伤敷料。
