• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

N-乙酰转移酶10促进微核形成以激活结肠癌细胞中的衰老相关分泌表型机制。

N-Acetyltransferase 10 Promotes Micronuclei Formation to Activate the Senescence-Associated Secretory Phenotype Machinery in Colorectal Cancer Cells.

作者信息

Cao Yanan, Yao Mengfei, Wu Yaqian, Ma Ningning, Liu Haijing, Zhang Bo

机构信息

Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China.

Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China.

出版信息

Transl Oncol. 2020 Aug;13(8):100783. doi: 10.1016/j.tranon.2020.100783. Epub 2020 May 16.

DOI:10.1016/j.tranon.2020.100783
PMID:32428852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7232111/
Abstract

The formation of micronuclei (MN) is prevalent in human cancer cells and its role in activating the senescence-associated secretory phenotype (SASP) machinery has been identified recently. However, the role of MN in regulation of SASP signaling still needs to define in practical cancers. Here, we reported that in colorectal cancer cells the expression of NAT10 (N-acetyltransferase 10) could mediate MN formation through DNA replication and NAT10-positive MN could activate SASP by binding to cGAS. The chemical inhibition of NAT10 by Remodelin or genomic depletion could markedly reduce MN formation, SASP activation, and senescence in colorectal cancer cells. Cell stress such as oxidative or hypoxia could upregulate NAT10 and its associated MN formation senescence and expression of SASP factors. Statistical analysis of clinical specimens revealed correlations between NAT10 expression, MN formation, SASP signaling, and the clinicopathological features of colorectal cancer. Our data suggest that NAT10 increasing MN formation and SASP pathway activation, promoting colorectal cancer progression.

摘要

微核（MN）的形成在人类癌细胞中很普遍，并且其在激活衰老相关分泌表型（SASP）机制中的作用最近已被确定。然而，MN在实际癌症中对SASP信号传导的调节作用仍有待明确。在此，我们报道在结肠直肠癌细胞中，NAT10（N-乙酰转移酶10）的表达可通过DNA复制介导MN形成，且NAT10阳性的MN可通过与cGAS结合激活SASP。Remodelin对NAT10的化学抑制或基因敲除可显著减少结肠直肠癌细胞中的MN形成、SASP激活和衰老。氧化或缺氧等细胞应激可上调NAT10及其相关的MN形成、衰老和SASP因子的表达。临床标本的统计分析揭示了NAT10表达、MN形成、SASP信号传导与结肠直肠癌临床病理特征之间的相关性。我们的数据表明，NAT10增加MN形成和SASP途径激活，促进结肠直肠癌进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/7232111/2d09f24a6e0c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/7232111/ff5a71419a01/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/7232111/6c0c654d3b19/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/7232111/63e66b87f5ac/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/7232111/8014a1ec9b87/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/7232111/77b1fe8d30e4/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/7232111/2d09f24a6e0c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/7232111/ff5a71419a01/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/7232111/6c0c654d3b19/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/7232111/63e66b87f5ac/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/7232111/8014a1ec9b87/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/7232111/77b1fe8d30e4/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/7232111/2d09f24a6e0c/gr6.jpg

相似文献

1
N-Acetyltransferase 10 Promotes Micronuclei Formation to Activate the Senescence-Associated Secretory Phenotype Machinery in Colorectal Cancer Cells.N-乙酰转移酶10促进微核形成以激活结肠癌细胞中的衰老相关分泌表型机制。
Transl Oncol. 2020 Aug;13(8):100783. doi: 10.1016/j.tranon.2020.100783. Epub 2020 May 16.
2
Inhibition of -Acetyltransferase 10 Suppresses the Progression of Prostate Cancer through Regulation of DNA Replication.乙酰基转移酶 10 的抑制通过调节 DNA 复制抑制前列腺癌的进展。
Int J Mol Sci. 2022 Jun 12;23(12):6573. doi: 10.3390/ijms23126573.
3
Expression of SASP, DNA Damage Response, and Cell Proliferation Factors in Early Gastric Neoplastic Lesions: Correlations and Clinical Significance.早期胃肿瘤病变中 SASP、DNA 损伤反应和细胞增殖因子的表达：相关性及临床意义。
Pathol Oncol Res. 2022 Aug 19;28:1610401. doi: 10.3389/pore.2022.1610401. eCollection 2022.
4
The hepatic senescence-associated secretory phenotype promotes hepatocarcinogenesis through Bcl3-dependent activation of macrophages.肝脏衰老相关分泌表型通过Bcl3依赖性激活巨噬细胞促进肝癌发生。
Cell Biosci. 2021 Sep 16;11(1):173. doi: 10.1186/s13578-021-00683-5.
5
Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer.细胞衰老和衰老相关分泌表型通过 cGAS-STING 信号通路在癌症中的作用。
Cancer Sci. 2020 Feb;111(2):304-311. doi: 10.1111/cas.14266. Epub 2019 Dec 27.
6
promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy-induced senescence-associated secretory phenotype via activation of DNA damage response pathway.通过激活 DNA 损伤反应途径，增强化疗诱导的衰老相关分泌表型的分泌，促进食管鳞状细胞癌的进展和化疗耐药性。
Gut Microbes. 2023 Jan-Dec;15(1):2197836. doi: 10.1080/19490976.2023.2197836.
7
Inhibition of N-acetyltransferase 10 using remodelin attenuates doxorubicin resistance by reversing the epithelial-mesenchymal transition in breast cancer.使用重塑素抑制N-乙酰基转移酶10可通过逆转乳腺癌中的上皮-间质转化来减弱阿霉素耐药性。
Am J Transl Res. 2018 Jan 15;10(1):256-264. eCollection 2018.
8
Autolysosomal degradation of cytosolic chromatin fragments antagonizes oxidative stress-induced senescence.溶酶体自噬降解胞质染色质片段拮抗氧化应激诱导的衰老。
J Biol Chem. 2020 Apr 3;295(14):4451-4463. doi: 10.1074/jbc.RA119.010734. Epub 2020 Feb 11.
9
Remodelin, a N-acetyltransferase 10 (NAT10) inhibitor, alters mitochondrial lipid metabolism in cancer cells.重塑酶，一种 N-乙酰基转移酶 10（NAT10）抑制剂，改变癌细胞中线粒体的脂质代谢。
J Cell Biochem. 2021 Dec;122(12):1936-1945. doi: 10.1002/jcb.30155. Epub 2021 Oct 4.
10
The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?衰老相关分泌表型（SASP）的作用及机制：它能被衰老细胞清除所控制吗？
Inflamm Regen. 2022 Apr 2;42(1):11. doi: 10.1186/s41232-022-00197-8.

引用本文的文献

1
Research progress on NAT10-mediated acetylation in normal development and disease.NAT10介导的乙酰化在正常发育和疾病中的研究进展
Front Cell Dev Biol. 2025 Aug 13;13:1623276. doi: 10.3389/fcell.2025.1623276. eCollection 2025.
2
Emerging role of N-acetyltransferase 10 in diseases: RNA ac4C modification and beyond.N-乙酰转移酶10在疾病中的新作用：RNA的ac4C修饰及其他
Mol Biomed. 2025 Jul 1;6(1):46. doi: 10.1186/s43556-025-00286-3.
3
Deciphering the role of acetylation-related gene NAT10 in colon cancer progression and immune evasion: implications for overcoming drug resistance.

本文引用的文献

1
Mild replication stress causes aneuploidy by deregulating microtubule dynamics in mitosis.轻度复制压力通过扰乱有丝分裂中的微管动力学引起非整倍体。
Cell Cycle. 2019 Oct;18(20):2770-2783. doi: 10.1080/15384101.2019.1658477. Epub 2019 Aug 25.
2
Mild replication stress causes chromosome mis-segregation via premature centriole disengagement.轻度复制应激通过过早的中心体脱离导致染色体错误分离。
Nat Commun. 2019 Aug 8;10(1):3585. doi: 10.1038/s41467-019-11584-0.
3
The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer.
解读乙酰化相关基因NAT10在结肠癌进展和免疫逃逸中的作用：对克服耐药性的启示
Discov Oncol. 2025 May 15;16(1):774. doi: 10.1007/s12672-025-02617-w.
4
NAT10 mediates TLR2 to promote podocyte senescence in adriamycin-induced nephropathy.NAT10介导Toll样受体2促进阿霉素诱导的肾病中足细胞衰老。
Cell Death Dis. 2025 Mar 19;16(1):185. doi: 10.1038/s41419-025-07515-1.
5
N4-acetylcytidine and other RNA modifications in epitranscriptome: insight into DNA repair and cancer development.表观转录组中的N4-乙酰胞苷及其他RNA修饰：对DNA修复和癌症发展的见解
Epigenomics. 2025 Apr;17(6):411-422. doi: 10.1080/17501911.2025.2473308. Epub 2025 Mar 5.
6
Identification of Novel lncRNAs Related to Colorectal Cancer Through Bioinformatics Analysis.通过生物信息学分析鉴定与结直肠癌相关的新型长链非编码RNA
Biomed Res Int. 2025 Jan 29;2025:5538575. doi: 10.1155/bmri/5538575. eCollection 2025.
7
The N-acetyltransferase 10 inhibitor [C]remodelin: synthesis and preliminary positron emission tomography study in mice.N-乙酰转移酶10抑制剂[C]重塑素：在小鼠体内的合成及正电子发射断层扫描初步研究
EJNMMI Radiopharm Chem. 2025 Jan 31;10(1):6. doi: 10.1186/s41181-025-00330-1.
8
Biological function and mechanism of NAT10 in cancer.NAT10在癌症中的生物学功能及机制
Cancer Innov. 2025 Jan 14;4(1):e154. doi: 10.1002/cai2.154. eCollection 2025 Feb.
9
Emerging Role of NAT10 as ac4C Writer in Inflammatory Diseases: Mechanisms and Therapeutic Applications.NAT10作为ac4C书写酶在炎症性疾病中的新作用：机制与治疗应用
Curr Drug Targets. 2025;26(4):282-294. doi: 10.2174/0113894501346709241202110834.
10
RNA modifications: emerging players in the regulation of reproduction and development.RNA修饰：生殖与发育调控中的新兴参与者
Acta Biochim Biophys Sin (Shanghai). 2024 Nov 21;57(1):33-58. doi: 10.3724/abbs.2024201.
cGAS-cGAMP-STING 通路将 DNA 损伤与炎症、衰老和癌症联系起来。
J Exp Med. 2018 May 7;215(5):1287-1299. doi: 10.1084/jem.20180139. Epub 2018 Apr 5.
4
G2/M-Phase Checkpoint Adaptation and Micronuclei Formation as Mechanisms That Contribute to Genomic Instability in Human Cells.G2/M 期检验点适应和微核形成作为导致人类细胞基因组不稳定性的机制。
Int J Mol Sci. 2017 Nov 6;18(11):2344. doi: 10.3390/ijms18112344.
5
cGAS Conducts Micronuclei DNA Surveillance.cGAS 进行微核 DNA 监测。
Trends Cell Biol. 2017 Oct;27(10):697-698. doi: 10.1016/j.tcb.2017.08.007. Epub 2017 Sep 4.
6
Mitotic progression following DNA damage enables pattern recognition within micronuclei.DNA损伤后的有丝分裂进程能够实现微核内的模式识别。
Nature. 2017 Aug 24;548(7668):466-470. doi: 10.1038/nature23470. Epub 2017 Jul 31.
7
cGAS surveillance of micronuclei links genome instability to innate immunity.cGAS对微核的监测将基因组不稳定性与先天免疫联系起来。
Nature. 2017 Aug 24;548(7668):461-465. doi: 10.1038/nature23449. Epub 2017 Jul 24.
8
Cell cycle profiling by image and flow cytometry: The optimised protocol for the detection of replicational activity using 5-Bromo-2'-deoxyuridine, low concentration of hydrochloric acid and exonuclease III.通过图像和流式细胞术进行细胞周期分析：使用5-溴-2'-脱氧尿苷、低浓度盐酸和外切核酸酶III检测复制活性的优化方案。
PLoS One. 2017 Apr 20;12(4):e0175880. doi: 10.1371/journal.pone.0175880. eCollection 2017.
9
Fate of micronuclei and micronucleated cells.微核和有微核的细胞的命运。
Mutat Res Rev Mutat Res. 2017 Jan-Mar;771:85-98. doi: 10.1016/j.mrrev.2017.02.002. Epub 2017 Feb 13.
10
Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing.细胞质 DNA 感应的 cGAS-STING 途径的调控和功能。
Nat Immunol. 2016 Sep 20;17(10):1142-9. doi: 10.1038/ni.3558.