London Viktoriya, McLaren Rodney, Atallah Fouad, Cepeda Catherine, McCalla Sandra, Fisher Nelli, Stein Janet L, Haberman Shoshana, Minkoff Howard
Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, New York.
Department of Obstetrics and Gynecology, State University New York, Downstate Medical Center, Brooklyn, New York.
Am J Perinatol. 2020 Aug;37(10):991-994. doi: 10.1055/s-0040-1712164. Epub 2020 May 19.
This study was aimed to compare maternal and pregnancy outcomes of symptomatic and asymptomatic pregnant women with novel coronavirus disease 2019 (COVID-19).
This is a retrospective cohort study of pregnant women with COVID-19. Pregnant women were divided into two groups based on status at admission, symptomatic or asymptomatic. All testing was done by nasopharyngeal swab using polymerase chain reaction (PCR) for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Initially, nasopharyngeal testing was performed only on women with a positive screen (symptoms or exposure) but subsequently, testing was universally performed on all women admitted to labor and delivery. Chi-square and Wilcoxon's rank-sum tests were used to compare outcomes between groups.
Eighty-one patients were tested because of a positive screen (symptoms [ = 60] or exposure only [ = 21]) and 75 patients were universally tested (all asymptomatic). In total, there were 46 symptomatic women and 22 asymptomatic women (tested based on exposure only [ = 12] or as part of universal screening [ = 10]) with confirmed COVID-19. Of symptomatic women ( = 46), 27.3% had preterm delivery and 26.1% needed respiratory support while none of the asymptomatic women ( = 22) had preterm delivery or need of respiratory support ( = 0.007 and 0.01, respectively).
Pregnant women who presented with COVID19-related symptoms and subsequently tested positive for COVID-19 have a higher rate of preterm delivery and need for respiratory support than asymptomatic pregnant women. It is important to be particularly rigorous in caring for COVID-19 infected pregnant women who present with symptoms.
· Respiratory support is often needed for women who present with symptoms.. · Low rate of severe disease in women who present without symptoms.. · There were no neonatal infections on day 0 of life..
本研究旨在比较2019年新型冠状病毒病（COVID-19）有症状和无症状孕妇的孕产妇及妊娠结局。
这是一项对COVID-19孕妇的回顾性队列研究。根据入院时的状态，将孕妇分为有症状组或无症状组。所有检测均通过鼻咽拭子使用聚合酶链反应（PCR）检测严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。最初，仅对筛查呈阳性（有症状或有接触史）的女性进行鼻咽检测，但随后，对所有入院分娩的女性普遍进行检测。采用卡方检验和威尔科克森秩和检验比较两组间的结局。
81例患者因筛查呈阳性（有症状[=60例]或仅有接触史[=21例]）接受检测，75例患者接受普遍检测（均无症状）。共有46例有症状女性和22例无症状女性（仅基于接触史检测[=12例]或作为普遍筛查的一部分[=10例]）确诊为COVID-19。有症状女性（=46例）中，27.3%发生早产，26.1%需要呼吸支持，而无症状女性（=22例）均未发生早产或需要呼吸支持（分别为=0.007和0.01）。
出现COVID-19相关症状并随后检测出COVID-19呈阳性的孕妇比无症状孕妇有更高的早产率和呼吸支持需求。对出现症状的COVID-19感染孕妇进行特别严格的护理非常重要。
· 有症状的女性通常需要呼吸支持。· 无症状女性的重症率较低。· 出生第0天无新生儿感染。
