• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

用羟基磷灰石/胶原蛋白复合材料修复髂嵴缺损。

Repair of Iliac Crest Defects with a Hydroxyapatite/Collagen Composite.

作者信息

Murata Koichi, Fujibayashi Shunsuke, Otsuki Bungo, Shimizu Takayoshi, Matsuda Shuichi

机构信息

Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

出版信息

Asian Spine J. 2020 Dec;14(6):808-813. doi: 10.31616/asj.2019.0310. Epub 2020 May 21.

DOI:10.31616/asj.2019.0310
PMID:32429017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7788373/
Abstract

STUDY DESIGN

Retrospective study.

PURPOSE

This study aimed to assess the effect of refilling with hydroxyapatite/collagen (HAp/Col) composite on an iliac crest defect after spinal fusion.

OVERVIEW OF LITERATURE

The use of iliac crest bone graft has been the gold standard in spinal fusion for a long time because of its biological and non-immunologic properties. Few reports have addressed how bone defects recover after iliac crest bone harvest following spinal fusion.

METHODS

Cancellous bone was collected from the anterior iliac crest during lateral interbody fusion (LIF), and the bone void of the ilium was refilled with a porous HAp/Col composite. We assessed bone recovery using computed tomography (CT). From the 74 patients who underwent LIF between January 2015 and December 2016, we included 49 patients whose iliac crest could be evaluated using CT at 3 months and 1 year after the surgery.

RESULTS

Bone defects decreased in a time-dependent manner after the surgery. Cortical closure was observed in 28.5% of the cases 3 months after the surgery; at 1 year postoperatively, 95.9% of the patients had cortical closure. Complete repair of the cancellous bone was achieved in 57.1% of the patients at 3 months after the surgery and in 95.9% at 1 year after the surgery. There were no significant hematomas, infections, iliac crest fractures, or soft tissue herniation.

CONCLUSIONS

Radiographic recovery of cortical and cancellous bone defects was achieved with high probability via refilling with HAp/Col composite over the 1-year period.

摘要

研究设计

回顾性研究。

目的

本研究旨在评估用羟基磷灰石/胶原蛋白(HAp/Col)复合材料填充对脊柱融合术后髂嵴缺损的影响。

文献综述

由于其生物学和非免疫特性,长期以来髂嵴骨移植一直是脊柱融合的金标准。很少有报道探讨脊柱融合术后髂嵴取骨后骨缺损如何恢复。

方法

在外侧椎间融合术(LIF)期间从髂前嵴采集松质骨,并用多孔HAp/Col复合材料填充髂骨的骨缺损。我们使用计算机断层扫描(CT)评估骨恢复情况。在2015年1月至2016年12月期间接受LIF的74例患者中,我们纳入了49例在术后3个月和1年可以用CT评估髂嵴的患者。

结果

术后骨缺损呈时间依赖性减少。术后3个月,28.5%的病例观察到皮质闭合;术后1年,95.9%的患者出现皮质闭合。术后3个月,57.1%的患者实现了松质骨的完全修复,术后1年为95.9%。没有明显的血肿、感染、髂嵴骨折或软组织疝。

结论

通过用HAp/Col复合材料填充,在1年期间皮质和松质骨缺损有很高概率实现影像学恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac0/7788373/d164a7ac7c6e/asj-2019-0310f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac0/7788373/d14608e3bef5/asj-2019-0310f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac0/7788373/009e55092b71/asj-2019-0310f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac0/7788373/156124796503/asj-2019-0310f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac0/7788373/d164a7ac7c6e/asj-2019-0310f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac0/7788373/d14608e3bef5/asj-2019-0310f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac0/7788373/009e55092b71/asj-2019-0310f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac0/7788373/156124796503/asj-2019-0310f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac0/7788373/d164a7ac7c6e/asj-2019-0310f4.jpg

相似文献

1
Repair of Iliac Crest Defects with a Hydroxyapatite/Collagen Composite.用羟基磷灰石/胶原蛋白复合材料修复髂嵴缺损。
Asian Spine J. 2020 Dec;14(6):808-813. doi: 10.31616/asj.2019.0310. Epub 2020 May 21.
2
Backfilling of iliac crest defects with hydroxyapatite-calcium triphosphate biphasic compound: a prospective, randomized computed tomography and patient-based analysis.用羟基磷灰石-磷酸三钙双相化合物填充髂嵴缺损:前瞻性、随机计算机断层扫描和基于患者的分析。
Spine J. 2013 Jan;13(1):54-61. doi: 10.1016/j.spinee.2012.10.019. Epub 2012 Nov 16.
3
Iliac crest bone graft donor site pain after anterior lumbar interbody fusion: a prospective patient satisfaction outcome assessment.腰椎前路椎间融合术后髂嵴骨移植供区疼痛:一项前瞻性患者满意度结果评估。
J Spinal Disord Tech. 2005 Feb;18 Suppl:S77-81. doi: 10.1097/01.bsd.0000112045.36255.83.
4
Difference in the fusion rate and bone formation between artificial bone and iliac autograft inside an inter-body fusion cage - A comparison between porous hydroxyapatite/type 1 collagen composite and autologous iliac bone.椎间融合器内人工骨与自体髂骨移植在融合率和骨形成方面的差异——多孔羟基磷灰石/Ⅰ型胶原复合材料与自体髂骨的比较
J Orthop Sci. 2018 Jul;23(4):622-626. doi: 10.1016/j.jos.2018.03.006. Epub 2018 Apr 4.
5
Coronal Plane Gap Increases Postoperative Pseudoarthrosis after Lateral Interbody Fusion for Adult Spinal Deformity.冠状面间隙增加成人脊柱畸形后路外侧椎间融合术后的假关节形成。
Asian Spine J. 2022 Jun;16(3):386-393. doi: 10.31616/asj.2020.0336. Epub 2021 May 6.
6
Clinical and radiographic analysis of an optimized rhBMP-2 formulation as an autograft replacement in posterolateral lumbar spine arthrodesis.一种优化的重组人骨形态发生蛋白-2制剂作为腰椎后路脊柱融合术中自体骨替代物的临床和影像学分析
J Bone Joint Surg Am. 2009 Jun;91(6):1377-86. doi: 10.2106/JBJS.H.00200.
7
Posterior lumbar interbody fusion using recombinant human bone morphogenetic protein type 2 with cylindrical interbody cages.使用重组人骨形态发生蛋白2与圆柱形椎间融合器进行腰椎后路椎间融合术。
Spine J. 2004 Sep-Oct;4(5):527-38; discussion 538-9. doi: 10.1016/j.spinee.2004.03.025.
8
Harvesting Autogenous Cancellous Bone Graft from the Anterior Iliac Crest.从髂前嵴获取自体松质骨移植骨。
JBJS Essent Surg Tech. 2018 Jul 11;8(3):e20. doi: 10.2106/JBJS.ST.17.00068. eCollection 2018 Sep 28.
9
[Minimally Invasive Cancellous Bone Graft Harvesting in Trauma Indication - Clinical Part of the Study].[创伤适应症下微创松质骨采集——研究的临床部分]
Acta Chir Orthop Traumatol Cech. 2020;87(2):108-113.
10
Postoperative pain following posterior iliac crest bone graft harvesting in spine surgery: a prospective, randomized trial.后路髂嵴骨取骨术后脊柱手术中的疼痛:一项前瞻性、随机试验。
Spine J. 2018 Jun;18(6):986-992. doi: 10.1016/j.spinee.2017.10.011. Epub 2017 Nov 14.

引用本文的文献

1
Transforming spinal surgery with innovations in biologics and additive manufacturing.通过生物制剂和增材制造方面的创新变革脊柱外科手术。
Mater Today Bio. 2025 May 13;32:101853. doi: 10.1016/j.mtbio.2025.101853. eCollection 2025 Jun.
2
Nano-hydroxyapatite/natural polymer composite scaffolds for bone tissue engineering: a brief review of recent trend.用于骨组织工程的纳米羟基磷灰石/天然聚合物复合支架:近期趋势简要综述
In Vitro Model. 2023 Apr 13;2(5):125-151. doi: 10.1007/s44164-023-00049-w. eCollection 2023 Nov.
3
Efficacy and Safety of Beta-Tricalcium Phosphate/Polylactic-Co-Glycolic Acid for Implantation of Bone Defects.

本文引用的文献

1
Bone Graft Substitutes in Single- or Double-Level Anterior Cervical Discectomy and Fusion: A Systematic Review.单节段或双节段前路颈椎间盘切除融合术中的骨移植替代物:一项系统评价。
Spine (Phila Pa 1976). 2019 May 15;44(10):E618-E628. doi: 10.1097/BRS.0000000000002925.
2
Reconstruction of iliac crest defect after autogenous harvest with bone cement and screws reduces donor site pain.采用骨水泥和螺钉修复自体取骨后髂嵴缺损可减轻供区疼痛。
BMC Musculoskelet Disord. 2018 Jul 19;19(1):237. doi: 10.1186/s12891-018-2167-7.
3
Difference in the fusion rate and bone formation between artificial bone and iliac autograft inside an inter-body fusion cage - A comparison between porous hydroxyapatite/type 1 collagen composite and autologous iliac bone.
β-磷酸三钙/聚乳酸-羟基乙酸共聚物用于骨缺损植入的有效性和安全性
Cureus. 2023 Aug 16;15(8):e43597. doi: 10.7759/cureus.43597. eCollection 2023 Aug.
4
Hinged Roof Reconstruction of Anterior Iliac Crest after Harvesting Bicortical Strut Graft for Anterior Cervical Fusion.前路颈椎融合术取双侧皮质支撑骨移植后髂前嵴带铰链式屋顶重建术
Spine Surg Relat Res. 2023 Jan 12;7(2):179-182. doi: 10.22603/ssrr.2022-0132. eCollection 2023 Mar 27.
5
Novel Surgical Technique for Adolescent Idiopathic Scoliosis: Minimally Invasive Scoliosis Surgery.青少年特发性脊柱侧凸的新型手术技术:微创脊柱侧弯手术
J Clin Med. 2022 Oct 2;11(19):5847. doi: 10.3390/jcm11195847.
6
Evaluation of the efficacy and safety of Escherichia coli-derived recombinant human bone morphogenetic protein-2 in transforaminal lumbar interbody fusion to treat degenerative spinal disease: a protocol of prospective, randomized controlled, assessor-blinded, open-label, multicenter trial.评价大肠杆菌来源的重组人骨形态发生蛋白-2 在经椎间孔腰椎体间融合术治疗退行性脊柱疾病中的疗效和安全性:一项前瞻性、随机对照、评估者盲法、开放标签、多中心试验方案。
J Orthop Surg Res. 2022 Aug 31;17(1):397. doi: 10.1186/s13018-022-03289-w.
7
Three-dimensional printed polylactic acid scaffold integrated with BMP-2 laden hydrogel for precise bone regeneration.三维打印聚乳酸支架与负载骨形态发生蛋白-2的水凝胶相结合用于精确骨再生。
Biomater Res. 2021 Oct 27;25(1):35. doi: 10.1186/s40824-021-00233-7.
椎间融合器内人工骨与自体髂骨移植在融合率和骨形成方面的差异——多孔羟基磷灰石/Ⅰ型胶原复合材料与自体髂骨的比较
J Orthop Sci. 2018 Jul;23(4):622-626. doi: 10.1016/j.jos.2018.03.006. Epub 2018 Apr 4.
4
Bone graft materials for posterolateral fusion made simple: a systematic review.简化后外侧融合的骨移植材料:一项系统综述
Eur Spine J. 2018 Aug;27(8):1856-1867. doi: 10.1007/s00586-018-5511-6. Epub 2018 Feb 14.
5
Biomaterials and Bioactive Agents in Spinal Fusion.脊柱融合中的生物材料和生物活性剂。
Tissue Eng Part B Rev. 2017 Dec;23(6):540-551. doi: 10.1089/ten.TEB.2017.0072. Epub 2017 Jun 28.
6
Modified Iliac Crest Reconstruction with Bone Cement for Reduction of Donor Site Pain and Morbidity after Open Wedge High Tibial Osteotomy: A Prospective Study.使用骨水泥改良髂嵴重建术以减轻开放性楔形高位胫骨截骨术后供区疼痛及并发症:一项前瞻性研究
Knee Surg Relat Res. 2016 Dec 1;28(4):277-282. doi: 10.5792/ksrr.15.046.
7
Efficacy and safety of porous hydroxyapatite/type 1 collagen composite implantation for bone regeneration: A randomized controlled study.多孔羟基磷灰石/Ⅰ型胶原复合材料植入促进骨再生的有效性和安全性:一项随机对照研究。
J Orthop Sci. 2016 May;21(3):373-80. doi: 10.1016/j.jos.2016.01.007. Epub 2016 Mar 5.
8
Bone graft substitutes for spine fusion: A brief review.用于脊柱融合的骨移植替代物:简要综述。
World J Orthop. 2015 Jul 18;6(6):449-56. doi: 10.5312/wjo.v6.i6.449.
9
Effect of indirect neural decompression through oblique lateral interbody fusion for degenerative lumbar disease.经斜外侧椎间融合术间接神经减压治疗退变性腰椎疾病的效果
Spine (Phila Pa 1976). 2015 Feb 1;40(3):E175-82. doi: 10.1097/BRS.0000000000000703.
10
Updates in the use of bone grafts in the lumbar spine.腰椎骨移植应用的最新进展。
Bull Hosp Jt Dis (2013). 2013;71(1):39-48.