Malling Brian, Røder Martin Andreas, Lauridsen Carsten, Lönn Lars
Department of Diagnostic Radiology, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Department of Urology, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Diagnostics (Basel). 2020 May 15;10(5):304. doi: 10.3390/diagnostics10050304.
Prostate artery embolization (PAE) is an emerging therapy for benign prostatic hyperplasia (BPH). Optimal patient selection is an important step when introducing new treatments and several characteristics associated with a good clinical outcome has previously been proposed. However, no prognostic tool is yet available for PAE. Computed tomography perfusion is an imaging technique that provides hemodynamic parameters making it possible to estimate the prostatic blood flow (PBF). This study investigated the relationship between PBF and the response to PAE. A post hoc analysis including prostate-specific antigen (PSA) measurements before and 24-h after embolization from two prospective studies on sixteen patients undergoing PAE with BPH or prostate cancer were performed. The primary outcome was the correlation between baseline PBF and the change in PSA as a surrogate measure of treatment response. Prostate volume strongly correlated with treatment response and the response was greater with incremental amounts of injected embolic material. PBF was not associated with elevation in PSA and added no information that could guide patient selection.
前列腺动脉栓塞术（PAE）是一种治疗良性前列腺增生（BPH）的新兴疗法。在引入新治疗方法时，优化患者选择是重要的一步，此前已提出了一些与良好临床结果相关的特征。然而，目前尚无用于PAE的预后工具。计算机断层扫描灌注是一种成像技术，可提供血流动力学参数，从而能够估计前列腺血流量（PBF）。本研究调查了PBF与PAE反应之间的关系。对两项前瞻性研究中16例接受PAE治疗的BPH或前列腺癌患者栓塞前和栓塞后24小时的前列腺特异性抗原（PSA）测量值进行了事后分析。主要结果是基线PBF与PSA变化之间的相关性，PSA变化作为治疗反应的替代指标。前列腺体积与治疗反应密切相关，随着注入栓塞材料量的增加，反应更大。PBF与PSA升高无关，也未提供可指导患者选择的信息。
