Fereig Ragab M, Nishikawa Yoshifumi
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.
Department of Animal Medicine, Faculty of Veterinary Medicine, South Valley University, Qena City, Qena 83523, Egypt.
Pathogens. 2020 May 16;9(5):384. doi: 10.3390/pathogens9050384.
is an intracellular protozoan parasite affecting numerous animal species. It induces significant economic losses because of abortion and neonatal abnormalities in cattle. In case of infection, the parasite secretes numerous arsenals to establish a successful infection in the host cell. In the same context but for a different purpose, the host resorts to different strategies to eliminate the invading parasite. During this battle, numerous key factors from both parasite and host sides are produced and interact for the maintaining and vanishing of the infection, respectively. Although several reviews have highlighted the role of different compartments of the immune system against infection, each one of them has mostly targeted specific points related to the immune component and animal host. Thus, in the current review, we will focus on effector molecules derived from the host cell or the parasite using a comprehensive survey method from previous reports. According to our knowledge, this is the first review that highlights and discusses immune response at the host cell-parasite molecular interface against infection in different susceptible hosts.
是一种影响众多动物物种的细胞内原生动物寄生虫。由于牛的流产和新生儿异常，它会导致重大经济损失。在感染情况下，寄生虫会分泌多种武器以在宿主细胞中成功建立感染。在相同背景下但出于不同目的，宿主会采取不同策略来消除入侵的寄生虫。在这场战斗中，寄生虫和宿主双方都会产生许多关键因素，并分别为维持和消除感染而相互作用。尽管有几篇综述强调了免疫系统不同部分对抗感染的作用，但它们大多针对与免疫成分和动物宿主相关的特定点。因此，在当前综述中，我们将使用来自先前报告的综合调查方法，专注于源自宿主细胞或寄生虫的效应分子。据我们所知，这是第一篇强调并讨论不同易感宿主中宿主细胞 - 寄生虫分子界面针对感染的免疫反应的综述。
