Rimayanti Rimayanti, Khairullah Aswin Rafif, Utama Suzanita, Ahmad Riza Zainuddin, Mulyati Sri, Damayanti Ratna, Lestari Tita Damayanti, Mustofa Imam, Hernawati Tatik, Wasito Wasito, Moses Ikechukwu Benjamin, Wardhani Bantari Wisynu Kusuma, Kurniasih Dea Anita Ariani, Kusumarini Shelly, Wibowo Syahputra, Yanestria Sheila Marty, Kusala Muhammad Khaliim Jati, Lisnanti Ertika Fitri, Fauziah Ima
Division of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.
Research Center for Veterinary Science, National Research and Innovation Agency (BRIN), Bogor, Indonesia.
Open Vet J. 2025 Mar;15(3):1078-1090. doi: 10.5455/OVJ.2025.v15.i3.2. Epub 2025 Mar 31.
The protozoan parasite is a cause of infectious disease neosporosis. is a major parasite affecting dogs and livestock worldwide. Neosporosis is a major cause of abortion in cattle, particularly in cattle raised in intensive agriculture. For diagnosis, the indirect enzyme-linked immunosorbent assay and immunofluorescence antibody test are employed. goes through three different stages in its life cycle: sporozoites, tachyzoite, and bradyzoite. The primary method of transmission in cattle is believed to be transplacental. Dogs are the definitive hosts of , and the organisms in dogs and cattle are indistinguishable from one another. A high prevalence of infection in animals was linked to the presence of dogs that tested positive for the parasite. Although exact statistics on the financial losses resulting from neosporosis in the global livestock sector are unavailable, losses are estimated to be millions of dollars. A number of medications have been investigated against . In infected cell cultures, piritrexim, monensin, pyrimethamine, and trimethoprim stop from growing intracellularly. Taking action to stop vertical transmission is the most practical way to control neosporosis in cattle herds, considering the current state of knowledge.
这种原生动物寄生虫是传染性疾病新孢子虫病的病因。它是一种影响全球犬类和家畜的主要寄生虫。新孢子虫病是牛流产的主要原因,尤其是在集约化农业中饲养的牛。诊断时采用间接酶联免疫吸附测定和免疫荧光抗体检测。它在生命周期中经历三个不同阶段:子孢子、速殖子和缓殖子。牛体内该寄生虫的主要传播方式被认为是经胎盘传播。犬类是该寄生虫的终末宿主,犬类和牛体内的病原体无法相互区分。动物中该寄生虫的高感染率与检测出寄生虫呈阳性的犬类的存在有关。尽管全球畜牧业因新孢子虫病造成的经济损失尚无确切统计数据,但估计损失达数百万美元。已经对多种药物进行了针对该寄生虫的研究。在受感染的细胞培养物中,喷他脒、莫能菌素、乙胺嘧啶和甲氧苄啶可阻止该寄生虫在细胞内生长。考虑到目前的知识水平,采取行动阻止垂直传播是控制牛群中新孢子虫病最切实可行的方法。