二维剪切波弹性成像与瞬时弹性成像：慢性丙型肝炎患者肝纤维化评估的非侵入性比较
Two-Dimensional Shear Wave Elastography versus Transient Elastography: A Non-Invasive Comparison for the Assessment of Liver Fibrosis in Patients with Chronic Hepatitis C.
作者信息
Villani Rosanna, Cavallone Francesco, Romano Antonino Davide, Bellanti Francesco, Serviddio Gaetano
机构信息
C.U.R.E. (University Centre for Liver Disease Research and Treatment), Liver Unit, Department of Medical and Surgical Sciences, University of Foggia, Viale Pinto 1, 71122 Foggia, Italy.
出版信息
Diagnostics (Basel). 2020 May 16;10(5):313. doi: 10.3390/diagnostics10050313.
In recent years, several non-invasive methods have been developed for staging liver fibrosis in patients with chronic hepatitis C. A 2D-Shear wave elastography (SWE) technique has been recently introduced on the EPIQ 7 US system (ElastQ), but its accuracy has not been validated in patients with chronic hepatitis C virus (HCV) infection. We enrolled 178 HCV patients to assess their liver fibrosis stage with ElastQ software using transient elastography as a reference standard. The best cut-off values to diagnose ³ F2, ³ F3, and F4 were 8.15, 10.31, and 12.65 KPa, respectively. Liver stiffness values had a positive correlation with transient elastography ( = 0.57; < 0.001). The area under the receiver operating characteristics (AUROC) was 0.899 for ³ F2 (moderate fibrosis), 0.900 for ³ F3 (severe fibrosis), and 0.899 for cirrhosis. 2D-SWE has excellent accuracy in assessing liver fibrosis in patients with chronic hepatitis C and an excellent correlation with transient elastography.
近年来，已经开发出几种用于对慢性丙型肝炎患者的肝纤维化进行分期的非侵入性方法。一种二维剪切波弹性成像（SWE）技术最近已被引入到EPIQ 7超声系统（ElastQ）上，但其准确性尚未在慢性丙型肝炎病毒（HCV）感染患者中得到验证。我们招募了178名HCV患者，以瞬时弹性成像作为参考标准，使用ElastQ软件评估他们的肝纤维化分期。诊断≥F2、≥F3和F4的最佳临界值分别为8.15、10.31和12.65千帕。肝脏硬度值与瞬时弹性成像呈正相关（r = 0.57；P < 0.001）。对于≥F2（中度纤维化），受试者工作特征曲线下面积（AUROC）为0.899，对于≥F3（重度纤维化）为0.900，对于肝硬化为0.899。二维SWE在评估慢性丙型肝炎患者的肝纤维化方面具有出色的准确性，并且与瞬时弹性成像具有良好的相关性。
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