Schiaffino Simone, Serpi Francesca, Rossi Duccio, Ferrara Valerio, Buonomenna Ciriaco, Alì Marco, Monfardini Lorenzo, Sconfienza Luca Maria, Mauri Giovanni
Radiology Unit, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.
Post-graduate School in Radiodiagnostics, Università degli Studi di Milano, 20122 Milan, Italy.
J Clin Med. 2020 May 16;9(5):1504. doi: 10.3390/jcm9051504.
The reproducibility of contrast-enhanced ultrasound (CEUS) and standard B-mode ultrasound in the assessment of radiofrequency-ablated volume of benign thyroid nodules was compared. A preliminary study was conducted on consecutive patients who underwent radiofrequency ablation (RFA) of benign thyroid nodules between 2014 and 2016, with available CEUS and B-mode post-ablation checks. CEUS and B-mode images were retrospectively evaluated by two radiologists to assess inter- and intra-observer agreement in the assessment of ablated volume (Bland-Altman test). For CEUS, the mean inter-observer difference (95% limits of agreement) was 0.219 mL (-0.372-0.809 mL); for B-mode, the mean difference was 0.880 mL (-1.655-3.414 mL). Reproducibility was significantly higher for CEUS (85%) than for B-mode (27%). Mean intra-observer differences (95% limits of agreement) were 0.013 mL (0.803-4.097 mL) for Reader 1 and 0.031 mL (0.763-3.931 mL) for Reader 2 using CEUS, while they were 0.567 mL (-2.180-4.317 mL, Reader 1) and 0.759 mL (-2.584-4.290 mL, Reader 2) for B-mode. Intra-observer reproducibility was significantly higher for CEUS (96% and 95%, for the two readers) than for B-mode (21% and 23%). In conclusion, CEUS had higher reproducibility and inter- and intra-observer agreement compared to conventional B-mode in the assessment of radiofrequency-ablated volume of benign thyroid nodules.
比较了超声造影（CEUS）和标准B模式超声在评估良性甲状腺结节射频消融体积方面的可重复性。对2014年至2016年间接受良性甲状腺结节射频消融（RFA）且有可用的CEUS和消融后B模式检查的连续患者进行了一项初步研究。两名放射科医生对CEUS和B模式图像进行回顾性评估，以评估在消融体积评估中的观察者间和观察者内一致性（Bland-Altman检验）。对于CEUS，观察者间平均差异（95%一致性界限）为0.219 mL（-0.372 - 0.809 mL）；对于B模式，平均差异为0.880 mL（-1.655 - 3.414 mL）。CEUS的可重复性（85%）显著高于B模式（27%）。使用CEUS时，观察者1的观察者内平均差异（95%一致性界限）为0.013 mL（0.803 - 4.097 mL），观察者2为0.031 mL（0.763 - 3.931 mL），而使用B模式时，观察者1为0.567 mL（-2.180 - 4.317 mL），观察者2为0.759 mL（-2.584 - 4.290 mL）。CEUS的观察者内可重复性（两位读者分别为96%和95%）显著高于B模式（21%和23%）。总之，在评估良性甲状腺结节射频消融体积方面，与传统B模式相比，CEUS具有更高的可重复性以及观察者间和观察者内一致性。
