Wu Changqiang, Li Danyang, Yang Li, Lin Bingbing, Zhang Houbing, Xu Ye, Cheng Zhuzhong, Xia Chunchao, Gong Qiyong, Song Bin, Ai Hua
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, P. R. China.
J Mater Chem B. 2015 Feb 28;3(8):1470-1473. doi: 10.1039/c4tb02036g. Epub 2015 Jan 27.
T contrast agents based on Mn(II) were conjugated on amphiphilic dextran micelles via click chemistry. The obtained paramagnetic nanomicelle contrast agent has a higher T relaxivity (13.3 Mn mmol s) and better sensitivity than those of free Mn(II) complexes. Studies carried out in vivo suggest that this contrast agent has a better and long-acting vascular enhancement effect at a lower manganese dosage (0.1 Mn mmol kg BW).
基于Mn(II)的T造影剂通过点击化学连接在两亲性葡聚糖胶束上。所得的顺磁性纳米胶束造影剂具有比游离Mn(II)配合物更高的T弛豫率（13.3 Mn mmol s）和更好的灵敏度。体内研究表明，该造影剂在较低的锰剂量（0.1 Mn mmol kg体重）下具有更好的长效血管增强效果。
